List of chemotherapeutic agents

Template:Seealso Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]; Steven Bellm, M.D. [3]

Overview

This is a list of chemotherapeutic agents that are known to be of use in chemotherapy for cancer. A full alphabetical listing is included after the categorical listing.

The agents in this list are often combined into chemotherapy regimens for polychemotherapy (combination chemotherapy).

Chemotherapeutic Agents by Category

Alkylating agents

Nitrogen mustards

• Chlorambucil (Leukeran)
• Cyclophosphamide (Cytoxan)
• Ifosfamide (Iflex)
• Melphalan (Alkeran)
• Mechlorethamine (Mustargen)

Ethylenimines

• Thiotepa (Tepadina)

Methylhydrazines

• Procarbazine (Matulane)

Alkylsulfonates

• Busulfan (Myleran)

Nitrosoureas

• Bendamustine (Treanda)
• Carmustine (BiCNU)
• Lomustine (CeeNU)
• Streptozocin (Zanosar)

Triazenes

• Altretamine (Hexalen)
• Dacarbazine (Dtic-Dome)
• Temozolomide (Temodar)

Platinum coordination complexes

• Carboplatin (Paraplatin)
• Cisplatin (Platinol)
• Oxaliplatin (Eloxatin)

---

Antimetabolites

Folic acid analogs

• Methotrexate (Mexate, Folex)
• Pemetrexed (Alimta)

Pyrimidine analogs

• Azacytidine (Vidaza)
• Capecitabine (Xeloda)
• Cytarabine (Cytosar)
• Floxuridine (FUDR)
• Fluorouracil (Adrucil, Efudex)
• Gemcitabine (Gemzar)

Purine analogs

• Cladribine (Leustatin)
• Clofarabine (Clolar)
• Fludarabine (Fludara)
• Mercaptopurine (Purinethol)
• Nelarabine (Arranon)
• Pentostatin (Nipent)
• Thioguanine (Tabloid)

Ribonucleotide reductase inhibitors

• Hydroxyurea (Hydrea)

---

Natural products

Vinca alkaloids

• Vinblastine (Velban, Velsar)
• Vincristine (Oncovin, Vincasar)
• Vincristine liposome (Marqibo)
• Vinflunine (Javlor)
• Vinorelbine (Navelbine)

Taxanes

• Docetaxel (Taxotere)
• Paclitaxel (Taxol, Onxol)

Epipodophyllotoxins

• Etoposide (Vespid)
• Teniposide (Vumon)

Camptothecins/Topoisomerase inhibitors

• Irinotecan (Camptosar)
• Topotecan (Hycamtin)

Antineoplastic antibiotics

• Bleomycin (Blenoxane)
• Dactinomycin (Cosmegen)
• Daunorubicin (Daunoxome)
• Doxorubicin (Adriamycin, Rubex)
• Epirubicin (Ellence)
• Idarubicin (Idamycin)
• Mitomycin C (Mutamycin)
• Mitoxantrone (Novantrone)
• Valrubicin (Valstar)

Antineoplastic enzymes

• L-Asparaginase (Elspar)
• Pegaspargase (Oncaspar)
• Glucarpidase (Voraxaze)

---

Hormones and Antagonists

Adrenocortical suppressants

• Mitotane (Lysodren)

Glucocorticoids

• Prednisone (Deltasone)

Progestins

• Medroxyprogesterone (Provera)
• Megestrol (Megace)

Anti-estrogens

• Tamoxifen (Nolvadex)
• Toremifene (Fareston)

Aromatase inhibitors

• Aminoglutethimide (Cytadren)
• Anastrozole (Arimidex)
• Exemestane (Aromasin)
• Letrozole (Femara)

Androgens

• Fluoxymesterone (Halotestin)
• Testolactone (Teslac)

Anti-androgens

• Abarelix (Plenaxis)
• Abiraterone (Zytiga)
• Bicalutamide (Casodex)
• Enzalutamide (Xtandi)
• Flutamide (Eulexin)
• Nilutamide (Nilandron)

LHRH agonists

• Triptorelin (Trelstar)

GnRH agonists

• Buserelin (Superfact)
• Goserelin (Zoladex)
• Leuprolide (Lupron)

GnRH antagonists

• Degarelix (Firmagon)

---

Biologics

Monoclonal antibodies

Anti-CD3 antibodies

• Catumaxomab (Removab)

Anti-CD3 & anti-CD19 antibodies

• Blinatumomab (Blincyto)

Anti-CD20 antibodies

• Rituximab (Rituxan)
• Ibritumomab (Zevalin)
• Obinutuzumab (Gazyva)
• Ofatumumab (Arzerra)
• Tositumomab (Bexxar)

Anti-CD30 antibodies

• Brentuximab (Adcetris)

Anti-CD33 antibodies

• Gemtuzumab (Mylotarg)

Anti-CD52 antibodies

• Alemtuzumab (Campath)

Anti-CTLA–4 antibodies

• Ipilimumab (Yervoy)

Anti-EGFR (ErbB1) antibodies

• Cetuximab (Erbitux)
• Panitumumab (Vectibix)

Anti-PD–1 antibodies

• Nivolumab (Opdivo)
• Pembrolizumab (Keytruda)

Anti-HER2/neu (ErbB2) antibodies

• Ado-trastuzumab (Kadcyla)
• Trastuzumab (Herceptin)

Anti-VEGF antibodies

• Bevacizumab (Avastin)

IL-2 inhibitors

• Aldesleukin (Proleukin)
• Denileukin diftitox (Ontak)

IL-6 inhibitors

• Siltuximab (Sylvant)
• Tocilizumab (Actemra)

Immunotherapy

• Interferon alfa-2b (Intron A)

---

Hematopoietic Growth Factors

Erythrocyte growth factors

• Erythropoietin (Procrit)

Granulocyte growth factors

• Filgrastim (Granix)
• Sargramostin (Leukine)
• Tbo-filgrastim (Granix)

Megakaryocyte growth factors

• Eltrombopag (Promacta)

---

Supportive Medications

Chemotherapy protective agents

• Amifostine (Ethyol)
• Cyanocobalamin
• Dexrazoxane (Zinecard)
• Folinic acid (Leucovorin)
• Glucarpidase (Voraxaze)
• Levoleucovorin (Fusilev)
• Mesna (Mesnex)

Antiemetic agents

• Netupitant and palonosetron (Akynzeo)

RANK ligand inhibitors

• Denosumab (Xgeva)

---

Miscellaneous

Mitotic inhibitors

• Amsacrine (Amsidine)
• Cabazitaxel (Jevtana)
• Eribulin (Halaven)
• Ixabepilone (Ixempra)

Bisphosphonates

• Zoledronic Acid (Zometa)

HDAC inhibitors

• Belinostat (Beleodaq)
• Romidepsin (Istodax)
• Vorinostat (Zolinza)

Hedgehog pathway inhibitors

• Vismodegib (Erivedge)

Immunomodulatory drugs (IMiDs)

• Lenalidomide (Revlimid)
• Pomalidomide (Pomalyst)
• Thalidomide (Thalomid)

Kinase inhibitors

• Afatinib (Gliotrif)
• Axitinib (Inlyta)
• Bosutinib (Bosulif)
• Cabozantinib (Cometriq)
• Ceritinib (Zykadia)
• Crizotinib (Xalkori)
• Dabrafenib (Tafinlar)
• Dasatinib (Sprycel)
• Erlotinib (Tarceva)
• Gefitinib (Iressa)
• Ibrutinib (Imbruvica)
• Idelalisib (Zydelig)
• Lapatinib (Tykerb)
• Nilotinib (Tasigna)
• Palbociclib (Ibrance)
• Sorafenib (Nexavar)
• Sunitinib (Sutent)
• Trametinib (Mekinist)
• Vandetanib (Caprelsa)
• Vemurafenib (Zelboraf)
• Ziv-aflibercept (Zaltrap)

mTOR Inhibitors

• Temsirolimus (Torisel)
• Everolimus (Afinitor)

Photosensitizing agents

• Aminolevulinic acid (Levulan)

Proteasome inhibitors

• Bortezomib (Velcade)
• Carfilzomib (Kyprolis)

Radioactive agents

• Radium-223 chloride (Xofigo)

Somatostatin analogs

• Octreotide (Octreotide)

VEGF receptor-2 antagonists

• Ramucirumab (Cyramza)

Differentiating agents

• Arsenic trioxide (Trisenox)
• Bexarotene (Targretin)
• Tretinoin (Vesanoid)

Chemotherapeutic Agents in Alphabetical Order

The unnamed parameter 2= is no longer supported. Please see the documentation for {{columns-list}}.

3