Pancytopenia: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
Line 23: Line 23:


===Causes by Organ System===
===Causes by Organ System===
 
{|style="width:80%; height:100px" border="1"
{|style="width:75%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
 
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
 
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
|-
|-
 
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
|-bgcolor="LightSteelBlue"
 
| '''Chemical/Poisoning'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Dental'''
| '''Dental'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| [[Acetaminophen and Oxycodone]], Aclarubicin, [[Albendazole]], [[Alemtuzumab]], [[Alkylating antineoplastic agent]], Alkylators, [[Arsenicals]], [[Auranofin]], [[Azathioprine]], [[Aztreonam]], [[Boceprevir]], Busulphan, [[carbamazepine]], [[Carboplatin]], [[Cefadroxil]], [[Ceftazidime]], [[Certolizumab pegol]], [[Chlorpromazine]], [[Chloramphenicol]], [[Chlorpropamide]], [[Cidofovir]], [[Clomipramine]], [[Colchicine toxicity]], [[Cytotoxic drugs]] and [[radiation]], [[Dactinomycin]], [[Doxorubicin]], [[Ethosuximide]], [[Febuxostat]], [[Flucytosine]], [[Gold]], [[Gemifloxacin mesylate]], [[Idarubicin]], [[indomethacin ]], [[Interferon beta- 1a]], [[Lincomycin Hydrochloride]] [[Minocycline hydrochloride]], [[Non steroidal anti-inflammatory drugs]], [[Ofatumumab]], [[Omacetaxine]], [[Oxaprozin]], [[Oxcarbazepine]], [[Penicillamine]], [[phenacemide ]], Phenylbutazone, [[Piperacillin]], [[Pralatrexate]], [[ propylthiouracil ]], [[Pyrimethamine]], [[Rabeprazole]], [[Radium chloride]], [[ sulfonamides]], [[Tamoxifen]], [[Tolbutamide]], [[Tolazamide]], [[Trifluoperazine]], [[Trimethadione]], [[Thiothixene]], [[Valganciclovir hydrochloride]]
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Thyroid carcinoma]]
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Environmental'''
| '''Environmental'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Tobacco]] use, Environmental/occupational (eg, benzene)
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| '''Gastroenterologic'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Portal hypertension]], Intestinal [[lymphangiectasia]], [[ Hepatitis ]]
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Ataxia telangiectasia]], [[Barth syndrome]], [[Chediak-Higashi disease]], defect in synthesis of adenosylcobalamin, DNA repair deficiencies, [[Down syndrome]], [[Dubowitz syndrome]], [[familial]] monosomy 7, [[Fanconi anaemia]], genotoxic therapy, glutathione synthase deficiency, [[glycogen storage diseases]], mutagen exposure, [[mutagen]]-detoxification (GSTq1-null), [[neurofibromatosis 1]], [[Niemann-Pick disease]], Nijmege breakage syndrome, [[Noonan syndrome]], organic acid metabolism defect, [[Pearson syndrome]], [[Seckel syndrome]], [[Severe combined immunodeficiency]], T- B+ due to JAK3 deficiency, [[trisomy 8]] mosaicism, [[Wiskott-Aldrich syndrome]]
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
| '''Hematologic'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Sickle cell disease]], Reticular dysgenesis, [[Paroxysmal nocturnal haemoglobinuria]], [[Non-Hodgkin lymphoma]], Myelpathic [[anemia]],
 
[[Myeloma]], [[Myelofibrosis]], [[Myelodysplastic syndrome]], [[Megaloblastic anaemia]], [[Malignant histiocytosis]], Leucoerythroblastic [[anaemia]],
 
Large granular [[lymphocytic leukemia]], [[Langerhans cell histiocytosis]], Ineffective erythropoiesis, Hypoplastic [[myelodysplastic syndromes ]],
 
[[Hypersplenism]], [[Hodgkin lymphoma]], [[Histiocytosis X]], [[Hepatosplenic T-cell lymphoma]], [[Hemoglobin H disease]], Hematopoietic cell transplantation, [[Hairy cell leukaemia]], [[Haemoglobin SC disease]], [[Haemoglobin E disease]], [[Graft versus host disease]], Familial [[myelofibrosis]], Familial histiocytic reticulosis, [[Eosinophilic fasciitis ]], [[Cyclical neutropenia]], Congenital [[neutropenia]] (Kostmann's or Shwachman-Diamond syndrome), [[Common variable hypogammaglobulinaemia]], [[Chronic myeloid leukaemia]], [[Chronic lymphocytic leukaemia]], Bleeding (Excessive), [[Autoimmune lymphoproliferative syndrome]] type 2, [[Autoimmune lymphoproliferative syndrome]] type 1, [[Aplastic anemia]], Amegakaryocytic [[thrombocytopenia]], [[Aggressive NK-cell leukemia]], [[Acute lymphoblastic leukemia]]
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| '''Iatrogenic'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Q fever]], [[Parvovirus B19]] infection, Oklahoma tick fever, [[Mycobacterium tuberculosis]], [[Legionella pneumophila]], [[Lassa fever]], [[Human immunodeficiency virus ]], [[Epstein-Barr virus]] Seronegative,  [[Dengue]], [[Brucellosis]]
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
| '''Nutritional/Metabolic'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Vitamin C deficiency]], [[Vitamin B12 deficiency]], [[Marasmus]], [[Malabsorption syndrome]], [[Kwashiorkor]], [[Iron deficiency]],
 
[[Intrinsic factor]] deficiency, [[Folate deficiency]], [[Copper deficiency]]
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| '''Obstetric/Gynecologic'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Pregnancy ]]
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Thymoma ]], [[Prostate cancer]], Metastatic neoplasm, [[Melanoma]], [[Germ cell tumors]] (embryonal dysgenesis), [[Ewing sarcoma]], [[Chondrosarcoma]], Cancer treatment
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
| '''Psychiatric'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Anorexia nervosa]]
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
| '''Renal/Electrolyte'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Renal failure, chronic]]
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
| '''Rheumatology/Immunology/Allergy'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|[[Systemic lupus erythematosus]], [[Rheumatoid disease]], [[Osteopetrosis]] autosomal recessive 2, [[Osteopetrosis]] lethal
 
Osteoclastoma, [[Ankylosing spondylitis]]
 
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Sexual'''
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Trauma'''
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Urologic'''
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| '''Miscellaneous'''
 
|bgcolor="Beige"| No underlying causes
|bgcolor="Beige"|Topoisomerase II interactive agents, [[Plummer-Vinson syndrome]], [[Obesity]], [[Idiopathic ]], Glue vapors, Dyskeratosis congenita Shwachman-Diamond syndrome,  Diamond-Blackfan [[anemia]], [[Castleman disease]], [[Bloom's syndrome ]]
 
|-
|-
|}
|}


===Causes in Alphabetical Order===
{{col-begin|width=84%}}
{{col-break|width=33%}}
*[[Aclarubicin]]


*[[Acute lymphoblastic leukemia]]


*[[Aggressive NK-cell leukemia]]
===Causes in Alphabetical Order===
 
*[[Albendazole]]
 
*[[Alemtuzumab]]
 
*[[Alkylating antineoplastic agent]]
 
*Alkylators
 
*Amegakaryocytic [[thrombocytopenia ]]
 
*[[Ankylosing spondylitis]]
 
*[[Anorexia nervosa]]
 
*[[Aplastic anemia]]
 
*[[Arsenicals]]
 
*[[Ataxia telangiectasia]]
 
*[[Auranofin]]
 
*[[Autoimmune lymphoproliferative syndrome type 1]]
 
*[[Autoimmune lymphoproliferative syndrome type 2]]
 
*[[Azathioprine]]
 
*[[Aztreonam]]
 
*Benzene Solvents
 
*Beta-emitters (eg, radioactive P-32)
 
*[[Bleeding (Excessive)]]
 
*[[Bloom's syndrome ]]
 
*[[Boceprevir]]
 
*[[Brucellosis]]
 
*Busulphan
 
*Cancer treatment
 
*[[carbamazepine]]
 
*[[Carboplatin]]
 
*[[Castleman disease]]
 
*[[Cefadroxil]]
 
*[[Ceftazidime]]
 
*[[Chediak-Higashi disease]]
 
*[[Chloramphenicol]]
 
*[[Chlorpropamide]]
 
*[[Chondrosarcoma]]
 
*[[Chronic lymphocytic leukaemia]]
 
*[[Chronic myeloid leukaemia]]
 
*[[Cidofovir]]
 
*[[Clomipramine]]
 
*[[Colchicine toxicity]]
 
*[[Common variable hypogammaglobulinaemia]]
 
*Congenital [[neutropenia]] (Kostmann's or Shwachman-Diamond syndrome)
 
*[[Copper deficiency]]
 
*[[Cyclical neutropenia]]
 
*[[Cytotoxic]] drugs and [[radiation ]]
 
*Defect in synthesis of adenosylcobalamin
 
*[[Dengue]]
 
*[[Diamond-Blackfan anemia]]
 
*DNA repair deficiencies
 
*[[Down syndrome]] (trisomy 21)
 
*[[Doxorubicin]]
 
* [[Dyskeratosis congenita]]
 
* [[Shwachman-Diamond syndrome]]
 
{{col-break|width=33%}}
 
*Environmental/occupational (eg, benzene)
 
*[[Eosinophilic fasciitis ]]
 
*[[Epstein-Barr virus]] Seronegative
 
*[[Ewing sarcoma]]
 
*[[Familial]] histiocytic reticulosis
 
*[[Familial]] monosomy 7
 
*[[Familial]] [[myelofibrosis]]
 
*[[Fanconi anaemia]]
 
*[[Flucytosine]]
 
*[[Folate deficiency]]
 
*Genotoxic therapy
 
*[[Germ cell]] tumors (embryonal dysgenesis)
 
*Glue vapors
 
*Glutathione synthase deficiency
 
*[[Gold ]]
 
*[[Graft versus host disease]]
 
*[[Haemoglobin E disease]]
 
*[[Haemoglobin SC disease]]
 
*[[Hairy cell leukaemia]]
 
*Hematopoietic cell transplantation
 
*[[Hemoglobin H disease]]
 
*[[ Hepatitis ]]
 
*[[Hepatosplenic T-cell lymphoma]]
 
*[[Histiocytosis X]]
 
*[[Hodgkin lymphoma]]
 
*[[Human immunodeficiency virus ]]
 
*[[Hypersplenism]]
 
*Hypoplastic [[myelodysplastic syndromes ]]
 
*[[Idarubicin]]
 
*[[Idiopathic ]]
 
*[[indomethacin ]]
 
*Ineffective [[erythropoiesis]]
 
*Intestinal [[lymphangiectasia]]
 
*[[Infliximab]]
 
*Intrinsic factor deficiency
 
*[[Iron deficiency]]
 
*[[Kwashiorkor]]
 
*[[Langerhans cell histiocytosis]]
 
*Large granular lymphocytic [[leukemia]]
 
*[[Lassa fever]]
 
*[[Legionella pneumophila]]
 
*Leucoerythroblastic [[anaemia]]
 
*[[Malabsorption syndrome]]
 
*[[Malignant histiocytosis]]
 
*[[Marasmus]]
 
*[[Megaloblastic anaemia]]
 
*[[Melanoma]]
 
*Metastatic neoplasm
 
{{col-break|width=33%}}
 
*Mutagen exposure
 
*Mutagen-detoxification (GSTq1-null)
 
*[[Mycobacterium tuberculosis]]
 
*[[Myelodysplastic syndrome]]
 
*[[Myelofibrosis]]
 
*[[Myeloma]]
 
*Myelpathic [[anemia]]
 
*[[Neurofibromatosis 1]]
 
*[[Niemann-Pick disease]]
 
*[[Non steroidal anti-inflammatory drugs ]]
 
*[[Non-Hodgkin lymphoma]]
 
*[[Obesity]]
 
*Oklahoma [[tick fever]]
 
*Osteoclastoma
 
*[[Osteopetrosis]] lethal
 
*[[Osteopetrosis]], autosomal recessive 2
 
*[[Osteosarcoma]]
 
*[[Oxaprozin]]
 
*[[Paroxysmal nocturnal haemoglobinuria]]
 
*[[Parvovirus B19 infection]]
 
*[[phenacemide ]]
 
*[[phenylbutazone ]]
 
*[[Plummer-Vinson syndrome]]
 
*[[Portal hypertension]]
 
*[[Pregnancy ]]
 
*[[Prostate cancer]]
 
*[[Propylthiouracil]]
 
*[[Pyrimethamine]]
 
*[[Q fever]]
 
*[[Radium chloride]]
 
*[[Renal failure, chronic]]
 
*Reticular dysgenesis
 
*[[Rheumatoid disease]]
 
*[[Severe combined immunodeficiency]], T- B+ due to JAK3 deficiency
 
*[[Sickle cell disease]]
 
*[[Sulfonamides ]]
 
*[[Systemic lupus erythematosus]]
 
*[[Tamoxifen]]
 
*[[Thymoma ]]
 
*[[Thyroid carcinoma]]
 
*[[Tobacco use ]]
 
*Topoisomerase II interactive agents
 
*[[Trisomy]] 8 mosaicism
 
*[[Valganciclovir hydrochloride]]
 
*[[Vitamin B12 deficiency]]
 
*[[Vitamin C deficiency]]
 
*[[Wiskott-Aldrich syndrome]]
 
*[[Xeroderma pigmentosum]]
{{col-end}}


===Causes by Pathophysiology===
===Causes by Pathophysiology===

Revision as of 15:21, 9 March 2015

Pancytopenia is not equivalent with bone marrow suppression. Pancytopenia is a lab finding that may related to either bone marrow suppression or peripheral sequestration/destruction. For details about bone marrow suppression click here.

WikiDoc Resources for Pancytopenia

Articles

Most recent articles on Pancytopenia

Most cited articles on Pancytopenia

Review articles on Pancytopenia

Articles on Pancytopenia in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Pancytopenia

Images of Pancytopenia

Photos of Pancytopenia

Podcasts & MP3s on Pancytopenia

Videos on Pancytopenia

Evidence Based Medicine

Cochrane Collaboration on Pancytopenia

Bandolier on Pancytopenia

TRIP on Pancytopenia

Clinical Trials

Ongoing Trials on Pancytopenia at Clinical Trials.gov

Trial results on Pancytopenia

Clinical Trials on Pancytopenia at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Pancytopenia

NICE Guidance on Pancytopenia

NHS PRODIGY Guidance

FDA on Pancytopenia

CDC on Pancytopenia

Books

Books on Pancytopenia

News

Pancytopenia in the news

Be alerted to news on Pancytopenia

News trends on Pancytopenia

Commentary

Blogs on Pancytopenia

Definitions

Definitions of Pancytopenia

Patient Resources / Community

Patient resources on Pancytopenia

Discussion groups on Pancytopenia

Patient Handouts on Pancytopenia

Directions to Hospitals Treating Pancytopenia

Risk calculators and risk factors for Pancytopenia

Healthcare Provider Resources

Symptoms of Pancytopenia

Causes & Risk Factors for Pancytopenia

Diagnostic studies for Pancytopenia

Treatment of Pancytopenia

Continuing Medical Education (CME)

CME Programs on Pancytopenia

International

Pancytopenia en Espanol

Pancytopenia en Francais

Business

Pancytopenia in the Marketplace

Patents on Pancytopenia

Experimental / Informatics

List of terms related to Pancytopenia

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]

Overview

Pancytopenia is the reduction in numbers of all three bone marrow cell types (RBCs + WBCs + platelets). It is not a disease, but rather a lab finding that may related to 1) bone marrow suppression caused by either insufficient production (aplastic anemia), inability of cells or mature (myelodysplasia), or replacement of normal bone marrow with fibrosis (myelofibrosis) or 2) peripheral sequestration/destruction that is not related to the bone marrow (e.g. splenomegaly or hypersplenism). HIV (Human Immunodeficiency Virus) is itself a cause for pancytopenia. Chemotherapy is associated with pancytopenia. Pancytopenia usually requires a bone marrow biopsy in order to distinguish among different causes.

Causes

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying causes
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying causes
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying causes
Gastroenterologic No underlying causes
Genetic No underlying causes
Hematologic No underlying causes
Iatrogenic No underlying causes
Infectious Disease No underlying causes
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying causes
Obstetric/Gynecologic No underlying causes
Oncologic No underlying causes
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying causes
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying causes
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying causes


Causes in Alphabetical Order

Causes by Pathophysiology

Bone Marrow Failure

Peripheral Sequestration/Destruction

Causes by Mode of Inheritance

Congenital

Acquired

References


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Pancytopenia&oldid=1076259"