Sulfiram: Difference between revisions
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(Created page with "{{Drugbox | IUPAC_name = ''N'',''N'',''N''′,''N''′-tetraethyldicarbonotrithioic diamide | image = Sulfiram.svg <!--Clinical data--> | tradename = | Drugs.com =...") |
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{{Drugbox | {{Drugbox | ||
| IUPAC_name = ''N'',''N'',''N''′,''N''′-tetraethyldicarbonotrithioic diamide | | IUPAC_name = ''N'',''N'',''N''′,''N''′-tetraethyldicarbonotrithioic diamide | ||
| image = Sulfiram. | | image = Sulfiram.png | ||
<!--Clinical data--> | <!--Clinical data--> | ||
Revision as of 13:02, 11 March 2015
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| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Topical |
| ATCvet code | |
| Pharmacokinetic data | |
| Bioavailability | Very low |
| Excretion | Renal, unchanged |
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| ChemSpider | |
| UNII | |
| KEGG | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C10H20N2S3 |
| Molar mass | 264.47 g·mol−1 |
Sulfiram (INN) or monosulfiram, trade name Tetmosol, is an ectoparasiticide used in the treatment and prevention of scabies.[1] It is usually sold as a solution or medicated soap, sometimes in combination with benzyl benzoate.
Sulfiram is now rarely used, but, as of 2010[update], is still available in Brazil, India, and South Africa (as monotherapy) and France (with benzyl benzoate).[1]
Adverse effects
Dizziness, headache, fatigue and erythematous rash may occur.[2] A single case of toxic epidermal necrolysis was reported in 1968.[3]
Sulfiram is structurally related to disulfiram (Antabuse), and readily converts to disulfiram when exposed to light. Like disulfiram, it can produce an unpleasant reaction when consumed with alcohol.[1][4]
References
- ↑ 1.0 1.1 1.2 Sweetman, Sean C., ed. (2009). "Pesticides and repellents". Martindale: the complete drug reference (36th ed.). London: Pharmaceutical Press. p. 2050. ISBN 978-0-85369-840-1.
- ↑ [No authors listed] (2009). "Sarfiram - Bula". Bulário de Remédios Comerciais (in Portuguese). MedicinaNET. Retrieved 2010-08-11.
- ↑ Copeman PW (March 1968). "Toxic epidermal necrolysis caused by skin hypersensitivity to monosulfiram". British Medical Journal. 1 (5592): 623–4. doi:10.1136/bmj.1.5592.623. PMC 1985336. PMID 5637574.
- ↑ Mays DC, Nelson AN, Benson LM, Johnson KL, Naylor S, Lipsky JJ (November 1994). "Photolysis of sulfiram: a mechanism for its disulfiram-like reaction". Biochemical Pharmacology. 48 (10): 1917–25. doi:10.1016/0006-2952(94)90590-8. PMID 7986203.
External links
- Tetmosol* soap – South African Electronic Package Insert
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