Pancytopenia: Difference between revisions
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*[[Aclarubicin]] | *[[Aclarubicin]] | ||
*[[Acute lymphoblastic leukemia]] | *[[Acute lymphoblastic leukemia]] | ||
*[[Acute myeloid leukemia]] | *[[Acute myeloid leukemia]] <ref name="pmid24353701">{{cite journal| author=Das Makheja K, Kumar Maheshwari B, Arain S, Kumar S, Kumari S| title=The common causes leading to pancytopenia in patients presenting to tertiary care hospital. | journal=Pak J Med Sci | year= 2013 | volume= 29 | issue= 5 | pages= 1108-11 | pmid=24353701 | doi= | pmc=PMC3858928 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24353701 }} </ref> | ||
*[[Aggressive NK-cell leukemia]] | *[[Aggressive NK-cell leukemia]] | ||
*[[Albendazole]] | *[[Albendazole]] | ||
| Line 169: | Line 169: | ||
*[[Boceprevir]] | *[[Boceprevir]] | ||
*[[bone marrow disorders|Bone marrow tumor]] | *[[bone marrow disorders|Bone marrow tumor]] | ||
*[[Brucellosis]] | *[[Brucellosis]] <ref name="pmid24820461">{{cite journal| author=Guler S, Kokoglu OF, Ucmak H, Gul M, Ozden S, Ozkan F| title=Human brucellosis in Turkey: different clinical presentations. | journal=J Infect Dev Ctries | year= 2014 | volume= 8 | issue= 5 | pages= 581-8 | pmid=24820461 | doi=10.3855/jidc.3510 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24820461 }} </ref> | ||
*[[Busulfan]] | *[[Busulfan]] | ||
*[[Cancer]] | *[[Cancer]] | ||
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*[[Colchicine toxicity]] | *[[Colchicine toxicity]] | ||
*[[common variable immunodeficiency|Common variable hypogammaglobulinemia]] | *[[common variable immunodeficiency|Common variable hypogammaglobulinemia]] | ||
*[[Common variable immune deficiency]] | *[[Common variable immune deficiency]] <ref name="pmid24433602">{{cite journal| author=Bajaj P, Clement J, Bayerl MG, Kalra N, Craig TJ, Ishmael FT| title=High-grade fever and pancytopenia in an adult patient with common variable immune deficiency. | journal=Allergy Asthma Proc | year= 2014 | volume= 35 | issue= 1 | pages= 78-82 | pmid=24433602 | doi=10.2500/aap.2014.35.3704 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24433602 }} </ref> | ||
*[[Copper deficiency]] | *[[Copper deficiency]] | ||
*[[Cyclical neutropenia]] | *[[Cyclical neutropenia]] | ||
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*[[Eosinophilic fasciitis ]] | *[[Eosinophilic fasciitis ]] | ||
*[[tumors|Epiphyseal tumors]] | *[[tumors|Epiphyseal tumors]] | ||
*[[Epstein-Barr virus ]] | *[[Epstein-Barr virus]] <ref name="pmid24228130">{{cite journal| author=Zhang X, Wang Z, Wang L, Yao H| title=An adult case of systemic Epstein-Barr virus-positive T/natural killer-cell lymphoproliferative disorder with good outcome. | journal=Int J Clin Exp Pathol | year= 2013 | volume= 6 | issue= 11 | pages= 2620-4 | pmid=24228130 | doi= | pmc=PMC3816837 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24228130 }} </ref> | ||
*[[Ethosuximide]] | *[[Ethosuximide]] | ||
*[[Ewing's sarcoma]] | *[[Ewing's sarcoma]] | ||
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*[[Gemifloxacin mesylate]] | *[[Gemifloxacin mesylate]] | ||
*[[genotoxicity|Genotoxic therapy]] | *[[genotoxicity|Genotoxic therapy]] | ||
*[[Germ cell tumors ]] | *[[Germ cell tumors ]] <ref name="pmid24005437">{{cite journal| author=Suyama T, Obara N, Kawai K, Yamada K, Kusakabe M, Kurita N et al.| title=[Acute myeloid leukemia possibly originating from the same clone of testicular germ cell tumor]. | journal=Rinsho Ketsueki | year= 2013 | volume= 54 | issue= 8 | pages= 764-8 | pmid=24005437 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24005437 }} </ref> | ||
*[[solvent|Glue vapors]] | *[[solvent|Glue vapors]] | ||
*[[glutathione synthase|Glutathione synthase deficiency]] | *[[glutathione synthase|Glutathione synthase deficiency]] | ||
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*[[dyskerin|Hoyeraal-Hreidarsson syndrome]] | *[[dyskerin|Hoyeraal-Hreidarsson syndrome]] | ||
*[[Human immunodeficiency virus ]] | *[[Human immunodeficiency virus ]] | ||
*[[Hypersplenism]] | *[[Hypersplenism]] <ref name="pmid24238033">{{cite journal| author=Jain A, Naniwadekar M| title=An etiological reappraisal of pancytopenia - largest series reported to date from a single tertiary care teaching hospital. | journal=BMC Hematol | year= 2013 | volume= 13 | issue= 1 | pages= 10 | pmid=24238033 | doi=10.1186/2052-1839-13-10 | pmc=PMC4177001 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24238033 }} </ref> | ||
*[[myelodysplastic syndrome|Hypoplastic myelodysplastic syndromes]] | *[[myelodysplastic syndrome|Hypoplastic myelodysplastic syndromes]] | ||
*[[Idarubicin]] | *[[Idarubicin]] | ||
| Line 274: | Line 274: | ||
*[[mutagen|Mutagen-detoxification (GSTq1-null)]] | *[[mutagen|Mutagen-detoxification (GSTq1-null)]] | ||
*[[Mycobacterium tuberculosis]] | *[[Mycobacterium tuberculosis]] | ||
*[[Myelodysplastic syndrome]] | *[[Myelodysplastic syndrome]] <ref name="pmid24300826">{{cite journal| author=Germing U, Kobbe G, Haas R, Gattermann N| title=Myelodysplastic syndromes: diagnosis, prognosis, and treatment. | journal=Dtsch Arztebl Int | year= 2013 | volume= 110 | issue= 46 | pages= 783-90 | pmid=24300826 | doi=10.3238/arztebl.2013.0783 | pmc=PMC3855821 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24300826 }} </ref> | ||
*[[Myelofibrosis]] | *[[Myelofibrosis]] | ||
*[[Myeloma]] | *[[Myeloma]] | ||
| Line 295: | Line 295: | ||
*[[Panhypopituitarism]] | *[[Panhypopituitarism]] | ||
*[[Paroxysmal nocturnal hemoglobinuria]] | *[[Paroxysmal nocturnal hemoglobinuria]] | ||
*[[Parvovirus B19 infection]] | *[[Parvovirus B19 infection]] <ref name="pmid23730023">{{cite journal| author=Rajput R, Sehgal A, Jain D, Sen R, Gupta A| title=Acute parvovirus b19 infection leading to severe aplastic anemia in a previously healthy adult female. | journal=Indian J Hematol Blood Transfus | year= 2012 | volume= 28 | issue= 2 | pages= 123-6 | pmid=23730023 | doi=10.1007/s12288-011-0112-0 | pmc=PMC3332267 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23730023 }} </ref> | ||
*[[Pearson syndrome]] | *[[Pearson syndrome]] | ||
*[[Penicillamine]] | *[[Penicillamine]] | ||
| Line 347: | Line 347: | ||
*[[Vitamin B12 deficiency]] | *[[Vitamin B12 deficiency]] | ||
*[[Vitamin C deficiency]] | *[[Vitamin C deficiency]] | ||
*[[Whipple's disease]] | *[[Whipple's disease]] <ref name="pmid24765256">{{cite journal| author=Tun NT, Shukla S, Krishnakurup J, Pappachen B, Krishnamurthy M, Salib H| title=An unusual cause of pancytopenia: Whipple's disease. | journal=J Community Hosp Intern Med Perspect | year= 2014 | volume= 4 | issue= | pages= | pmid=24765256 | doi=10.3402/jchimp.v4.23482 | pmc=PMC3992356 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24765256 }} </ref> | ||
*[[Wiskott-Aldrich syndrome]] | *[[Wiskott-Aldrich syndrome]] | ||
*[[Xeroderma pigmentosum]] | *[[Xeroderma pigmentosum]] | ||
Revision as of 16:00, 12 March 2015
Pancytopenia is not equivalent with bone marrow suppression. Pancytopenia is a lab finding that may related to either bone marrow suppression or peripheral sequestration/destruction. For details about bone marrow suppression click here.
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Cafer Zorkun, M.D., Ph.D. [2] Ogheneochuko Ajari, MB.BS, MS [3]
Overview
Pancytopenia is the reduction in numbers of all three bone marrow cell types (RBCs + WBCs + platelets). It is not a disease, but rather a lab finding that may related to bone marrow suppression caused by either insufficient production (aplastic anemia), inability of cells or mature (myelodysplasia), or replacement of normal bone marrow with fibrosis (myelofibrosis) or peripheral sequestration/destruction that is not related to the bone marrow (e.g. splenomegaly or hypersplenism). HIV (human immunodeficiency virus) is itself a cause of pancytopenia. Chemotherapy is associated with pancytopenia. Pancytopenia usually requires a bone marrow biopsy in order to distinguish among different causes.
Causes
Life Threatening Causes
Life-threatening causes include conditions which may result in death or permanent disability within 24 hours if left untreated.
Common Causes
- Aplastic anemia [1]
- Folate deficiency
- Leishmaniasis
- Leukemia
- Megaloblastic anemia [1]
- Myelodysplastic syndrome
- Paroxysmal nocturnal hemoglobinuria
- Viral infections e.g. (HIV most common)
- Vitamin B12 deficiency
Causes by Organ System
Causes in Alphabetical Order
The unnamed parameter 2= is no longer supported. Please see the documentation for {{columns-list}}.
3Causes by Pathophysiology
Bone Marrow Failure
- Insufficient production (aplastic anemia)
- Inability of cells or mature (myelodysplasia)
- Replacement of normal bone marrow with fibrosis (myelofibrosis)
Peripheral Sequestration/Destruction
Causes by Mode of Inheritance
Congenital
- Cartilage hair hypoplasia
- Diamond-Blackfan syndrome
- Dubowitz syndrome
- Dyskeratosis congenita
- Familial aplastic anemia
- Fanconi's anemia
- Pearson syndrome
- Schwachman-Diamond syndrome
- TAR syndrome
Acquired
- Albers-Schonberg disease
- Banti's Syndrome
- Bone marrow tumor
- Cirrhosis
- Drugs/Toxins
- Felty's Syndrome
- Gaucher's Disease
- Graft-versus-host disease
- Infections
- Kala-Azar
- Leukemia
- Lymphoma
- Lymphoproliferative Disorders
- Myelodysplastic syndrome
- Myelofibrosis
- Niemann-Pick Disease
- Osteoporosis
- Pernicious anemia
- Reticulosis
- Sarcoidosis
- Thymoma
- Tuberculosis
References
- ↑ 1.0 1.1 1.2 Das Makheja K, Kumar Maheshwari B, Arain S, Kumar S, Kumari S (2013). "The common causes leading to pancytopenia in patients presenting to tertiary care hospital". Pak J Med Sci. 29 (5): 1108–11. PMC 3858928. PMID 24353701.
- ↑ Guler S, Kokoglu OF, Ucmak H, Gul M, Ozden S, Ozkan F (2014). "Human brucellosis in Turkey: different clinical presentations". J Infect Dev Ctries. 8 (5): 581–8. doi:10.3855/jidc.3510. PMID 24820461.
- ↑ Bajaj P, Clement J, Bayerl MG, Kalra N, Craig TJ, Ishmael FT (2014). "High-grade fever and pancytopenia in an adult patient with common variable immune deficiency". Allergy Asthma Proc. 35 (1): 78–82. doi:10.2500/aap.2014.35.3704. PMID 24433602.
- ↑ Zhang X, Wang Z, Wang L, Yao H (2013). "An adult case of systemic Epstein-Barr virus-positive T/natural killer-cell lymphoproliferative disorder with good outcome". Int J Clin Exp Pathol. 6 (11): 2620–4. PMC 3816837. PMID 24228130.
- ↑ Suyama T, Obara N, Kawai K, Yamada K, Kusakabe M, Kurita N; et al. (2013). "[Acute myeloid leukemia possibly originating from the same clone of testicular germ cell tumor]". Rinsho Ketsueki. 54 (8): 764–8. PMID 24005437.
- ↑ Jain A, Naniwadekar M (2013). "An etiological reappraisal of pancytopenia - largest series reported to date from a single tertiary care teaching hospital". BMC Hematol. 13 (1): 10. doi:10.1186/2052-1839-13-10. PMC 4177001. PMID 24238033.
- ↑ Germing U, Kobbe G, Haas R, Gattermann N (2013). "Myelodysplastic syndromes: diagnosis, prognosis, and treatment". Dtsch Arztebl Int. 110 (46): 783–90. doi:10.3238/arztebl.2013.0783. PMC 3855821. PMID 24300826.
- ↑ Rajput R, Sehgal A, Jain D, Sen R, Gupta A (2012). "Acute parvovirus b19 infection leading to severe aplastic anemia in a previously healthy adult female". Indian J Hematol Blood Transfus. 28 (2): 123–6. doi:10.1007/s12288-011-0112-0. PMC 3332267. PMID 23730023.
- ↑ Tun NT, Shukla S, Krishnakurup J, Pappachen B, Krishnamurthy M, Salib H (2014). "An unusual cause of pancytopenia: Whipple's disease". J Community Hosp Intern Med Perspect. 4. doi:10.3402/jchimp.v4.23482. PMC 3992356. PMID 24765256.