Colistimethate sodium

{{DrugProjectFormSinglePage |authorTag=Kiran Singh, M.D. [1] |aOrAn=a |indicationType=treatment |hasBlackBoxWarning=Yes |adverseReactions= |blackBoxWarningTitle=ConditionName: |blackBoxWarningBody=ConditionName:

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There is limited information regarding Off-Label Guideline-Supported Use of Colistimethate sodium in adult patients.

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There is limited information regarding Off-Label Non–Guideline-Supported Use of Colistimethate sodium in adult patients.

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There is limited information regarding FDA-Labeled Use of Colistimethate sodium in pediatric patients.

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Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Colistimethate sodium in pediatric patients.

|offLabelPedNoGuideSupport======Condition1=====

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Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Colistimethate sodium in pediatric patients.

|contraindications=* Condition1

|warnings=* Description

Precautions

• Description

|clinicalTrials=There is limited information regarding Clinical Trial Experience of Colistimethate sodium in the drug label.

Miscellaneous

|postmarketing=There is limited information regarding Postmarketing Experience of Colistimethate sodium in the drug label.

Miscellaneous

|drugInteractions=* Drug

• Description

|useInPregnancyFDA=* Pregnancy Category |useInPregnancyAUS=* Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Colistimethate sodium in women who are pregnant. |useInLaborDelivery=There is no FDA guidance on use of Colistimethate sodium during labor and delivery. |useInNursing=There is no FDA guidance on the use of Colistimethate sodium with respect to nursing mothers. |useInPed=There is no FDA guidance on the use of Colistimethate sodium with respect to pediatric patients. |useInGeri=There is no FDA guidance on the use of Colistimethate sodium with respect to geriatric patients. |useInGender=There is no FDA guidance on the use of Colistimethate sodium with respect to specific gender populations. |useInRace=There is no FDA guidance on the use of Colistimethate sodium with respect to specific racial populations. |useInRenalImpair=There is no FDA guidance on the use of Colistimethate sodium in patients with renal impairment. |useInHepaticImpair=There is no FDA guidance on the use of Colistimethate sodium in patients with hepatic impairment. |useInReproPotential=There is no FDA guidance on the use of Colistimethate sodium in women of reproductive potentials and males. |useInImmunocomp=There is no FDA guidance one the use of Colistimethate sodium in patients who are immunocompromised.

|administration=* Oral

• Intravenous

|monitoring=There is limited information regarding Monitoring of Colistimethate sodium in the drug label.

• Description

|IVCompat=There is limited information regarding IV Compatibility of Colistimethate sodium in the drug label.

|overdose====Acute Overdose===

Signs and Symptoms

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Management

• Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Colistimethate sodium in the drug label.

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|structure=Colistimethate for Injection, USP is a sterile parenteral antibiotic product which, when reconstituted (see RECONSTITUTION), is suitable for intramuscular or intravenous administration.

Each vial contains colistimethate sodium or pentasodium colistinmethanesulfonate (150 mg colistin base activity). The sodium content is approximately 0.099 mg (0.0043 mEq) of sodium per milligram of colistin.

Colistimethate Sodium, USP is pentasodium [[4-[[3-hydroxy-1-[[1-[[3-(1-hydroxyethyl)-12,15-bis(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-6,9,18-tris[2-(sulfonatomethylamino)ethyl]-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]-1-oxo-4-(sulfonatomethylamino)butan-2-yl]amino]-1-oxobutan-2-yl]amino]-3-(6-methyloctanoylamino)-4-oxobutyl]amino]methanesulfonate.

Colistimethate Sodium, USP is a polypeptide antibiotic with an approximate molecular weight of 1750. The molecular formula is C58H105N16Na5O28S5 and the structural formula is represented below:

This image is provided by the National Library of Medicine.

Colistimethate for Injection, USP is a white to slightly yellow lyophilized cake. The color of the reconstituted solution is clear colorless to pale yellow and essentially free from particles.

|PD=There is limited information regarding Pharmacodynamics of Colistimethate sodium in the drug label.

|PK=There is limited information regarding Pharmacokinetics of Colistimethate sodium in the drug label.

|nonClinToxic=There is limited information regarding Nonclinical Toxicology of Colistimethate sodium in the drug label.

|clinicalStudies=There is limited information regarding Clinical Studies of Colistimethate sodium in the drug label.

|howSupplied=* |packLabel= |fdaPatientInfo=There is limited information regarding Patient Counseling Information of Colistimethate sodium in the drug label.

|alcohol=* Alcohol-Colistimethate sodium interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

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|lookAlike=* A® — B®

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