Carbocisteine: Difference between revisions

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{{chembox
: [[File:Carbocystiene Wiki Str.png|none|right|500px]]
| Watchedfields = changed
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 740J2QX53R
| verifiedrevid = 443673182
| ImageFile =Carboxymethylcystein Formulae.png
| ImageSize = 200px
| ImageFile1 =Carbocisteine 3D.png
| ImageSize1 = 200px
| IUPACName = (''R'')-2-Amino-3-(carboxymethylsulfanyl)propanoic acid
| OtherNames = ''S''-Carboxymethyl-<small>L</small>-cysteine; Mucodyne, Solmux, Rhinathiol, Humex, Lisomucil, Fluditec, Exputex, Mucolit, Reodyn, Carbotoux, Flemex, Carbolin, Muflex
|Section1={{Chembox Identifiers
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D06393
| InChI1 = 1/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
| InChIKey1 = GBFLZEXEOZUWRN-VKHMYHEABX
| SMILES1 = O=C(O)[C@@H](N)CSCC(=O)O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = GBFLZEXEOZUWRN-VKHMYHEASA-N
| CASNo_Ref = {{cascite|correct|??}}
| CASNo =638-23-3
| CASNo_Comment = (''R'')
| CASNo1 = 2387-59-9
| CASNo1_Comment = (''RS'')
| PubChem = 193653
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 396416
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 168055
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 16163
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB04339
| SMILES =O=C(O)C(N)CSCC(=O)O
| InChI = 1/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)
| InChIKey = GBFLZEXEOZUWRN-UHFFFAOYAN
| ATCvet =
| ATCCode_prefix = R05
| ATCCode_suffix = CB03
| ATC_Supplemental =
  }}
|Section2={{Chembox Properties
| C =5|H=9|N=1|O=4|S=1
| Appearance =Colorless solid
| Density =
| MeltingPtC = 204 to 207
| Melting_notes =
| BoilingPtC =
| Solubility =
  }}
|Section3={{Chembox Hazards
| MainHazards =
| FlashPt =
| AutoignitionPt =
  }}
|Section5={{Chembox Pharmacology
| AdminRoutes =
| Bioavail =
| Metabolism =
| HalfLife =
| ProteinBound =
| Excretion =
| Legal_status =
| Legal_US =
| Legal_UK =
| Legal_AU =
| Legal_CA =
| PregCat =
| PregCat_AU =
| PregCat_US =
}}
}}
 
'''Carbocisteine''' is a [[mucolytic]] that reduces the viscosity of sputum and so can be used to help relieve the symptoms of [[chronic obstructive pulmonary disorder]] (COPD) and [[bronchiectasis]] by allowing the sufferer to bring up [[sputum]] more easily. Carbocisteine should not be used with [[antitussive]]s (cough suppressants) or medicines that dry up bronchial secretions.
'''Carbocisteine''' is a [[mucolytic]] that reduces the viscosity of sputum and so can be used to help relieve the symptoms of [[chronic obstructive pulmonary disorder]] (COPD) and [[bronchiectasis]] by allowing the sufferer to bring up [[sputum]] more easily. Carbocisteine should not be used with [[antitussive]]s (cough suppressants) or medicines that dry up bronchial secretions.


Revision as of 16:09, 8 April 2015

Carbocisteine is a mucolytic that reduces the viscosity of sputum and so can be used to help relieve the symptoms of chronic obstructive pulmonary disorder (COPD) and bronchiectasis by allowing the sufferer to bring up sputum more easily. Carbocisteine should not be used with antitussives (cough suppressants) or medicines that dry up bronchial secretions.

Carbocisteine is produced by alkylation of cysteine with chloroacetic acid.[1]

Trade names

  • Fluidol, Humotusin: Romania
  • Rhinathiol: Bulgaria, Congo, Hong Kong, Hungary, Latvia, Lithuania, Malaysia, Oman, Romania, Singapore, South Korea, Switzerland, Taiwan, Thailand, Tunisia, and Vietnam[2]
  • Mucodyne: United Kingdom, India, Ireland, Japan, Netherlands, Serbia.
  • Mucoral: Portugal
  • Mucosol: Egypt
  • Solmux, Loviscol: Philippines

References

  1. ↑ Karlheinz Drauz, Ian Grayson, Axel Kleemann, Hans-Peter Krimmer, Wolfgang Leuchtenberger, Christoph Weckbecker “Amino Acids” in Ullmann's Encyclopedia of Industrial Chemistry, 2007, Wiley-VCH, Weinheim. doi:10.1002/14356007.a02_057.pub2
  2. ↑ http://www.drugs.com/international/rhinathiol.html

Template:Cough and cold preparations

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