Trichlorfon: Difference between revisions

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Metrifonate
Clinical data
Synonyms	Trichlorphon
AHFS/Drugs.com	International Drug Names
ATC code	P02BB01 (WHO) Template:ATCvet Template:ATCvet;
Pharmacokinetic data
Elimination half-life	3 hours
Identifiers
	IUPAC name (RS)-Dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate;
CAS Number	52-68-6 ;
PubChem CID	5853;
ChemSpider	5644;
UNII	DBF2DG4G2K;
KEGG	C07971 ;
ChEBI	CHEBI:6908 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C4H8Cl3O4P
Molar mass	257.436 g/mol
3D model (JSmol)	Interactive image;
	SMILES COP(=O)(C(C(Cl)(Cl)Cl)O)OC InChI = 1/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3;
	InChI InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3; Key:NFACJZMKEDPNKN-UHFFFAOYSA-N;
(verify)

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VisualWikitext

Revision as of 16:05, 8 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Metrifonate (INN) or trichlorfon (USAN) is an irreversible organophosphate acetylcholinesterase inhibitor.^[1] It is a prodrug which is activated non-enzymatically into 2,2-dichlorovinyl dimethyl phosphate (DDVP).

It is used as an insecticide.

It can be used to treat schistosomiasis caused by Schistoma haematobium but is no longer commercially available.^[2]

It has been proposed for use in treatment of Alzheimer's disease, but use for that purpose is not currently recommended.^[3]

References

↑ "NLH - Neurological Conditions - Metrifonate for Alzheimer's disease".
↑ Ross A.G.P., Bartley P.B., Sleigh A.C., Olds G.R., Li Y., Williams G.M., and McManus D.P. (2002). "Schistosomiasis". The New England Journal of Medicine. 346 (16): 1212–1220. doi:10.1056/NEJMra012396. PMID 11961151.
↑ López-Arrieta J, Schneider L (2008). López-Arrieta, Jess, ed. "Metrifonate for Alzheimer's disease". Cochrane Database of Systematic Reviews (1): CD003155. doi:10.1002/14651858.CD003155.pub3. PMID 16625573.

Template:Anthelmintics

[urlNLH_-_Neurological_Conditions_-_Metrifonate_for_Alzheimers_disease-1] "NLH - Neurological Conditions - Metrifonate for Alzheimer's disease".

[urlschistosomiasis-2] Ross A.G.P., Bartley P.B., Sleigh A.C., Olds G.R., Li Y., Williams G.M., and McManus D.P. (2002). "Schistosomiasis". The New England Journal of Medicine. 346 (16): 1212–1220. doi:10.1056/NEJMra012396. PMID 11961151.

[3] López-Arrieta J, Schneider L (2008). López-Arrieta, Jess, ed. "Metrifonate for Alzheimer's disease". Cochrane Database of Systematic Reviews (1): CD003155. doi:10.1002/14651858.CD003155.pub3. PMID 16625573.

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[3]

@@ Line 58: / Line 58: @@
 }}
 __NOTOC__
 {{SI}}
 {{CMG}}
 ==Overview==
 '''Metrifonate''' ([[International Nonproprietary Name|INN]]) or '''trichlorfon''' ([[United States Adopted Name|USAN]]) is an irreversible [[organophosphate]] [[acetylcholinesterase inhibitor]].<ref name="urlNLH - Neurological Conditions - Metrifonate for Alzheimers disease">{{cite web |url=http://www.library.nhs.uk/neurological/ViewResource.aspx?resID=237789 |title=NLH - Neurological Conditions - Metrifonate for Alzheimer's disease |format= |work= |accessdate=}}</ref> It is a prodrug which is activated non-enzymatically into [[2,2-dichlorovinyl dimethyl phosphate]] ([[DDVP]]).
@@ Line 76: / Line 73: @@
 {{Anthelmintics}}
-{{Antidementia}}
-{{Cholinergics}}
 [[Category:Insecticides]]
@@ Line 83: / Line 78: @@
 [[Category:Organophosphate insecticides]]
 [[Category:Anticholinesterases]]
-[[Category:Acetylcholinesterase inhibitors]]
-[[Category:Phosphonate esters]]
 [[Category:Organochlorides]]
 [[Category:Drug]]

Trichlorfon: Difference between revisions

Revision as of 16:05, 8 April 2015

Overview

References

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