Acipimox: Difference between revisions

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List of terms related to Acipimox

Acipimox
	Skeletal formula
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral
ATC code	C10AD06 (WHO) ;
Identifiers
	IUPAC name 5-carboxy-2-methyl-1-oxidopyrazin-1-ium;
CAS Number	51037-30-0 ;
PubChem CID	5310993;
ChemSpider	4470534 ;
UNII	K9AY9IR2SD;
KEGG	D07190 ;
ChEMBL	ChEMBL345714 ;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C6H6N2O3
Molar mass	154.124 g/mol
3D model (JSmol)	Interactive image;
	SMILES [O-][n+]1c(cnc(C(=O)O)c1)C;
	InChI InChI=1S/C6H6N2O3/c1-4-2-7-5(6(9)10)3-8(4)11/h2-3H,1H3,(H,9,10) ; Key:DJQOOSBJCLSSEY-UHFFFAOYSA-N ;
(verify)

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VisualWikitext

Latest revision as of 14:34, 10 April 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Acipimox is a niacin derivative used as a hypolipidemic agent. It is used in low doses and may have less marked adverse effects, although it is unclear whether the recommended dose is as effective as are standard doses of nicotinic acid. Acipimox inhibits the production of triglycerides by the liver and the secretion of VLDL, which leads indirectly to a modest reduction in LDL and increase in HDL. Long-term administration is associated with reduced mortality, but unwanted effects limit its clinical use. Adverse effects include flushing (associated with Prostaglandin D2), palpitations, and GI disturbances. Flushing can be reduced by taking aspirin 20-30 min before taking Acipimox. High doses can cause disorders of liver function, impair glucose tolerance and precipitate gout.

References

Template:Lipid modifying agents

@@ Line 1: / Line 1: @@
-{{drugbox
+{{Drugbox
-| IUPAC_name        = 5-methylpyrazine-2-carboxylic acid 4-oxide
+| Watchedfields = changed
-| image             = Acipimox.png
+| verifiedrevid = 442738806
-| CAS_number        = 51037-30-0
+| IUPAC_name = 5-carboxy-2-methyl-1-oxidopyrazin-1-ium
-| ATC_prefix        = C10
+| image =Acipimox.png
-| ATC_suffix        = AD06
+| alt = Skeletal formula
-| PubChem           = 5310993
+| width = 180
-| DrugBank          =
+| image2 =Acipimox-3D-spacefill.png
-| C=6|H=6|N=2|O=3
+| alt2 = Ball-and-stick model
-| molecular_weight  = 154.124 g/mol
+<!--Clinical data-->
-| bioavailability   =
+| tradename =
-| protein_bound     =
+| Drugs.com = {{drugs.com|international|acipimox}}
-| metabolism        =
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
-| elimination_half-life =
+| pregnancy_US = <!-- A / B            / C / D / X -->
-| excretion         =
+| pregnancy_category =
-| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
-| pregnancy_US      =  <!-- A / B            / C / D / X -->
+| legal_CA = <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
-| pregnancy_category=
+| legal_UK = <!-- GSL         / P       / POM / CD / Class A, B, C -->
-| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
+| legal_US = <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
-| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
+| legal_status =
-| legal_UK          =  <!-- GSL         / P       / POM / CD / Class A, B, C -->
+| routes_of_administration = Oral
-| legal_US          =  <!-- OTC                   / Rx-only  / Schedule I, II, III, IV, V -->
-| legal_status      =
+<!--Pharmacokinetic data-->
-| routes_of_administration =
+| bioavailability =
-}}
+| protein_bound =
-__NOTOC__
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
+| CAS_number = 51037-30-0
+| ATC_prefix = C10
+| ATC_suffix = AD06
+| PubChem = 5310993
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
+| DrugBank =
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
+| ChemSpiderID = 4470534
+| UNII_Ref = {{fdacite|correct|FDA}}
+| UNII = K9AY9IR2SD
+| KEGG_Ref = {{keggcite|correct|kegg}}
+| KEGG = D07190
+| ChEMBL_Ref = {{ebicite|correct|EBI}}
+| ChEMBL = 345714
+<!--Chemical data-->
+| C=6 | H=6 | N=2 | O=3
+| molecular_weight = 154.124 g/mol
+| smiles = [O-][n+]1c(cnc(C(=O)O)c1)C
+| InChI = 1/C6H6N2O3/c1-4-2-7-5(6(9)10)3-8(4)11/h2-3H,1H3,(H,9,10)
+| InChIKey = DJQOOSBJCLSSEY-UHFFFAOYAA
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChI = 1S/C6H6N2O3/c1-4-2-7-5(6(9)10)3-8(4)11/h2-3H,1H3,(H,9,10)
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
+| StdInChIKey = DJQOOSBJCLSSEY-UHFFFAOYSA-N
+}}__NOTOC__
 {{SI}}
 {{CMG}}

Acipimox: Difference between revisions

Latest revision as of 14:34, 10 April 2015

Overview

References

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