Sandbox brain abscess

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Abscess Main Page
Brain abscess Microchapters
Home
Patient Information
Overview
Historical Perspective
Pathophysiology
Causes
Differentiating Brain abscess from other Diseases
Epidemiology and Demographics
Risk Factors
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
CT
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Sandbox brain abscess On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Sandbox brain abscess All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Sandbox brain abscess
CDC on Sandbox brain abscess
Sandbox brain abscess in the news
Blogs on Sandbox brain abscess
Directions to Hospitals Treating Brain abscess
Risk calculators and risk factors for Sandbox brain abscess

Overview

Treatment of brain abscess requires a multidisciplinary approach to delineate extent of infection, plan stereotactic trajectory, aspirate purulent materials, lower intracranial pressure, identify causative pathogen, and administer appropriate antibiotics.

Antimicrobial Therapy – Empiric Therapy

Cefotaxime 8–12 g/day q4–6h OR Ceftriaxone 4 g/day q12h AND

Metronidazole 30 mg/kg/day q6h

Meropenem 6 g/day q8h

Cefotaxime 8–12 g/day q4–6h OR Ceftriaxone 4 g/day q12h AND

Metronidazole 30 mg/kg/day q6h AND

Voriconazole 8 mg/kg/day q12h AND

TMP-SMZ 10–20 mg/kg/day q6–12h OR Sulfadiazine 4–6 g/day q6h

Cefotaxime 8–12 g/day q4–6h OR Ceftriaxone 4 g/day q12h AND

Sulfadiazine 4–6 g/day q6h AND

Pyrimethamine 25–100 mg/day qd

Vancomycin 30–45 mg/kg/day q8–12h

Isoniazid 300 mg qd AND

Rifampin 600 mg qd AND

Pyrazinamide 15–30 mg qd AND

Ethambutol 15 mg/kg/day qd

Antimicrobial Therapy – Pathogen-Based Therapy

Penicillin G 24 MU q4h

Metronidazole 30 mg/kg/day q6h

Cefotaxime 8–12 g/day q4–6h OR Ceftriaxone 4 g/day q12h

Metronidazole 30 mg/kg/day q6h

Cefotaxime 8–12 g/day q4–6h OR Ceftriaxone 4 g/day q12h

Ampicillin 12 g/day q4h OR Penicillin G 24 MU q4h

TMP-SMZ 10–20 mg/kg/day q6–12h OR Sulfadiazine 4–6 g/day q6h

Metronidazole 30 mg/kg/day q6h

Ceftazidime 6 g/day q8h OR Cefepime 6 g/day q8h

Nafcillin 12 g/day q4h OR Oxacillin 12 g/day q4h

Vancomycin 30–45 mg/kg/day q8–12h

Penicillin G 24 MU q4h

Voriconazole 8 mg/kg/day q12h

Amphotericin B lipid complex 5 mg/kd/day q24h OR Amphotericin B deoxycholate 15 mg/kg/day q8h

Amphotericin B lipid complex 5 mg/kd/day q24h OR Amphotericin B deoxycholate 15 mg/kg/day q8h

Amphotericin B lipid complex 5 mg/kd/day q24h OR Amphotericin B deoxycholate 15 mg/kg/day q8h

Voriconazole 8 mg/kg/day q12h

Sulfadiazine 4–6 g/day q6h
<span style="text-indent: 50px;}}AND

Pyrimethamine 25–100 mg/day qd