Gastroesophageal reflux disease causes: Difference between revisions
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==Overview== | ==Overview== | ||
==Causes== | ==Causes== | ||
*Hereditary sensory and autonomic neuropathy type 1B | * Hereditary sensory and autonomic neuropathy type 1B | ||
*Systemic sclerosis | * Systemic sclerosis | ||
*Autonomic neuropathy | * Autonomic neuropathy | ||
*Esophageal achalasia | * Esophageal achalasia | ||
*Hiatus hernia | * [[Ibuprofen lysine]] | ||
*Pharyngeal pouch | * Hiatus hernia | ||
*Another paradoxical cause of GERD-like symptoms is not enough stomach acid ([[hypochlorhydria]]). The valve that empties the stomach into the intestines is triggered by acidity. If there is not enough acid, this valve does not open and the stomach contents are churned up into the esophagus. However, there is still enough acidity to irritate the esophagus. | * Pharyngeal pouch | ||
*[[Hiatus hernia]], which increases the likelihood of GERD due to mechanical and motility factors<ref name="pmid17573791">{{cite journal |author=Piesman M, Hwang I, Maydonovitch C, Wong RK |title=Nocturnal reflux episodes following the administration of a standardized meal. Does timing matter? |journal=Am. J. Gastroenterol. |volume=102 |issue=10 |pages=2128-2134 |year=2007 |pmid=17573791 |doi=10.1111/j.1572-0241.2007.01348.x}}</ref> | * Another paradoxical cause of GERD-like symptoms is not enough stomach acid ([[hypochlorhydria]]). The valve that empties the stomach into the intestines is triggered by acidity. If there is not enough acid, this valve does not open and the stomach contents are churned up into the esophagus. However, there is still enough acidity to irritate the esophagus. | ||
*[[Obesity]]: increasing [[body mass index]] is associated with more severe GERD<ref name="pmid175737910">{{cite journal |author=Ayazi S, Crookes P, Peyre C, |title=Objective documentation of the link between gastroesophageal reflux disease and obesity |journal=Am. J. Gastroenterol. |volume=102 |issue=S |pages=138-139 |year=2007 }}</ref> | * [[Hiatus hernia]], which increases the likelihood of GERD due to mechanical and motility factors<ref name="pmid17573791">{{cite journal |author=Piesman M, Hwang I, Maydonovitch C, Wong RK |title=Nocturnal reflux episodes following the administration of a standardized meal. Does timing matter? |journal=Am. J. Gastroenterol. |volume=102 |issue=10 |pages=2128-2134 |year=2007 |pmid=17573791 |doi=10.1111/j.1572-0241.2007.01348.x}}</ref> | ||
*[[Zollinger-Ellison syndrome]], which can be present with increased gastric acidity due to [[gastrin]] production | * [[Obesity]]: increasing [[body mass index]] is associated with more severe GERD<ref name="pmid175737910">{{cite journal |author=Ayazi S, Crookes P, Peyre C, |title=Objective documentation of the link between gastroesophageal reflux disease and obesity |journal=Am. J. Gastroenterol. |volume=102 |issue=S |pages=138-139 |year=2007 }}</ref> | ||
*[[Hypercalcemia]], which can increase [[gastrin]] production, leading to increased acidity | * [[Zollinger-Ellison syndrome]], which can be present with increased gastric acidity due to [[gastrin]] production | ||
*[[Scleroderma]] and [[systemic sclerosis]], which can feature esophageal dysmotility | * [[Hypercalcemia]], which can increase [[gastrin]] production, leading to increased acidity | ||
* [[Scleroderma]] and [[systemic sclerosis]], which can feature esophageal dysmotility | |||
===Causes by Organ System=== | ===Causes by Organ System=== | ||
Revision as of 01:22, 28 April 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Causes
- Hereditary sensory and autonomic neuropathy type 1B
- Systemic sclerosis
- Autonomic neuropathy
- Esophageal achalasia
- Ibuprofen lysine
- Hiatus hernia
- Pharyngeal pouch
- Another paradoxical cause of GERD-like symptoms is not enough stomach acid (hypochlorhydria). The valve that empties the stomach into the intestines is triggered by acidity. If there is not enough acid, this valve does not open and the stomach contents are churned up into the esophagus. However, there is still enough acidity to irritate the esophagus.
- Hiatus hernia, which increases the likelihood of GERD due to mechanical and motility factors[1]
- Obesity: increasing body mass index is associated with more severe GERD[2]
- Zollinger-Ellison syndrome, which can be present with increased gastric acidity due to gastrin production
- Hypercalcemia, which can increase gastrin production, leading to increased acidity
- Scleroderma and systemic sclerosis, which can feature esophageal dysmotility
Causes by Organ System
| Cardiovascular | No underlying causes |
| Chemical/Poisoning | No underlying causes |
| Dental | No underlying causes |
| Dermatologic | No underlying causes |
| Drug Side Effect | Apremilast, febuxostat, ibuprofen lysine, naproxen and esomeprazole magnesium, pirfenidone, pramipexole, ritonavir, |
| Ear Nose Throat | No underlying causes |
| Endocrine | No underlying causes |
| Environmental | No underlying causes |
| Gastroenterologic | No underlying causes |
| Genetic | No underlying causes |
| Hematologic | No underlying causes |
| Iatrogenic | No underlying causes |
| Infectious Disease | No underlying causes |
| Musculoskeletal/Orthopedic | No underlying causes |
| Neurologic | No underlying causes |
| Nutritional/Metabolic | No underlying causes |
| Obstetric/Gynecologic | No underlying causes |
| Oncologic | No underlying causes |
| Ophthalmologic | No underlying causes |
| Overdose/Toxicity | No underlying causes |
| Psychiatric | No underlying causes |
| Pulmonary | No underlying causes |
| Renal/Electrolyte | No underlying causes |
| Rheumatology/Immunology/Allergy | No underlying causes |
| Sexual | No underlying causes |
| Trauma | No underlying causes |
| Urologic | No underlying causes |
| Miscellaneous | No underlying causes |
References
- ↑ Piesman M, Hwang I, Maydonovitch C, Wong RK (2007). "Nocturnal reflux episodes following the administration of a standardized meal. Does timing matter?". Am. J. Gastroenterol. 102 (10): 2128–2134. doi:10.1111/j.1572-0241.2007.01348.x. PMID 17573791.
- ↑ Ayazi S, Crookes P, Peyre C, (2007). "Objective documentation of the link between gastroesophageal reflux disease and obesity". Am. J. Gastroenterol. 102 (S): 138–139.