Nephrotic syndrome causes: Difference between revisions
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Nephrotic syndrome}} | {{Nephrotic syndrome}} | ||
{{CMG}}; {{AE}} [[User:YazanDaaboul|Yazan Daaboul]], [[User:Sergekorjian|Serge Korjian]] | {{CMG}}; {{AE}}{{MJ}}, [[User:YazanDaaboul|Yazan Daaboul]], [[User:Sergekorjian|Serge Korjian]] | ||
==Overview== | ==Overview== | ||
| Line 7: | Line 7: | ||
==Causes== | ==Causes== | ||
Nephrotic syndrome can occur primarily or due to systemic diseases. The most common cause of nephrotic syndrome in children is minimal change disease. The most common primary causes in adults are: focal segmental glomerulosclerosis (FSGS), minimal change disease, and membranous nephropathy. approximaelty 30 percent of adults have secondary nephrotic syndrome due to diabetes mellitus, SLE, or amyloidosis. | |||
<s>[2-9].</s> | |||
===Primary Causes=== | ===Primary Causes=== | ||
Primary renal disorders, such as primary [[glomerulonephritides]], may cause primary nephrotic syndrome. Differentiation between different types of glomerular diseases is often made by clinical suspicion and by renal biopsy, which includes [[light microscopy]], [[immunofluorescence]], and ideally [[electron microscopy]]. | Primary renal disorders, such as primary [[glomerulonephritides]], may cause primary nephrotic syndrome. Differentiation between different types of glomerular diseases is often made by clinical suspicion and by renal biopsy, which includes [[light microscopy]], [[immunofluorescence]], and ideally [[electron microscopy]]. | ||
| Line 12: | Line 16: | ||
===Secondary Causes=== | ===Secondary Causes=== | ||
Secondary causes of renal disorders cause secondary nephrotic syndrome. The most common cause of secondary nephrotic syndrome in adults is [[diabetes mellitus]]. Shown below is a table of the causes of nephrotic syndrome by age group. | Secondary causes of renal disorders cause secondary nephrotic syndrome. The most common cause of secondary nephrotic syndrome in adults is [[diabetes mellitus]]. Shown below is a table of the causes of nephrotic syndrome by age group. | ||
{| border="1" style="border-collapse:collapse; text-align:left;" cellpadding="5" align="center" | {| border="1" style="border-collapse:collapse; text-align:left;" cellpadding="5" align="center" | ||
|+ '''''Common Causes of Nephrotic Syndrome by Age''''' | |+ '''''Common Causes of Nephrotic Syndrome by Age''''' | ||
| bgcolor="#d9ff54"|'''Age (Years)''' || bgcolor="#d9ff54"|'''Cause of Nephrotic Syndrome''' | | bgcolor="#d9ff54" |'''Age (Years)''' || bgcolor="#d9ff54" |'''Cause of Nephrotic Syndrome''' | ||
|- | |- | ||
| bgcolor="#ececec"|'''< 15 ''' || | | bgcolor="#ececec" |'''< 15 ''' || | ||
*[[Congenital]] nephrotic syndrome | *[[Congenital]] nephrotic syndrome | ||
*[[Minimal change disease]] | *[[Minimal change disease]] | ||
| Line 24: | Line 27: | ||
*[[Membranous nephropathy]] | *[[Membranous nephropathy]] | ||
|- | |- | ||
| bgcolor="#ececec"|'''15-40''' || | | bgcolor="#ececec" |'''15-40''' || | ||
*[[Focal segmental glomerulosclerosis]] | *[[Focal segmental glomerulosclerosis]] | ||
*[[Lupus nephritis]] | *[[Lupus nephritis]] | ||
| Line 34: | Line 37: | ||
*[[IgA nephropathy]] | *[[IgA nephropathy]] | ||
|- | |- | ||
| bgcolor="#ececec"|'''> 40 ''' || | | bgcolor="#ececec" |'''> 40 ''' || | ||
*[[Focal segmental glomerulosclerosis]] | *[[Focal segmental glomerulosclerosis]] | ||
*[[Membranous nephropathy]] | *[[Membranous nephropathy]] | ||
Revision as of 20:24, 15 May 2018
|
Nephrotic Syndrome Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Nephrotic syndrome causes On the Web |
|
American Roentgen Ray Society Images of Nephrotic syndrome causes |
|
Risk calculators and risk factors for Nephrotic syndrome causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mehrian Jafarizade, M.D [2], Yazan Daaboul, Serge Korjian
Overview
Nephrotic syndrome can be either primary or secondary to diseases. Primary renal disorders, such as primary glomerulonephritides, may cause primary nephrotic syndrome. The most common cause of secondary nephrotic syndrome in adults is diabetes mellitus.
Causes
Nephrotic syndrome can occur primarily or due to systemic diseases. The most common cause of nephrotic syndrome in children is minimal change disease. The most common primary causes in adults are: focal segmental glomerulosclerosis (FSGS), minimal change disease, and membranous nephropathy. approximaelty 30 percent of adults have secondary nephrotic syndrome due to diabetes mellitus, SLE, or amyloidosis.
[2-9].
Primary Causes
Primary renal disorders, such as primary glomerulonephritides, may cause primary nephrotic syndrome. Differentiation between different types of glomerular diseases is often made by clinical suspicion and by renal biopsy, which includes light microscopy, immunofluorescence, and ideally electron microscopy.
Secondary Causes
Secondary causes of renal disorders cause secondary nephrotic syndrome. The most common cause of secondary nephrotic syndrome in adults is diabetes mellitus. Shown below is a table of the causes of nephrotic syndrome by age group.
| Age (Years) | Cause of Nephrotic Syndrome |
| < 15 |
|
| 15-40 | |
| > 40 |
List of Secondary Causes of Nephrotic Syndrome[1]
- Adaptation to nephron reduction
- Amyloidosis
- Bee sting
- Castleman's disease
- Chronic interstitial nephritis
- Dermatomyositis
- Diabetes mellitus
- Endocarditis
- Fabry's disease
- Food allergens
- Gold
- Goodpasture's syndrome
- Graft vs. host disease
- Henoch-Schonlein purpura
- Heroin
- HIV
- Infectious mononucleosis
- Interferon
- Kimura's disease
- Leukemia
- Lipoatrophy
- Lithium
- Lymphomas
- Malaria
- Mercury
- Mixed connective tissue disease
- Multiple myeloma
- NSAID
- Obesity
- Oligomeganephronia
- Orthostatic proteinuria
- Penicillamine
- Polyarteritis nodosa
- Pre-eclampsia
- Probenecid
- Renal vein thrombosis
- Rheumatoid arthritis
- Sarcoidosis
- Sickle cell anemia
- Sjogren's syndrome
- Sorafenib
- Streptococcal Infection
- Syphillis
- Systemic lupus erythematosus
- Thyroid disease
- Toxoplasmosis
- Vasculitis
- Viral hepatitis
Drug Induced
- Agalsidase beta
- Certolizumab pegol
- coagulation factor IX
- Olsalazine
- Sodium aurothiomalate
- Trimethadione
- Ziv-aflibercept
References
- ↑ Eddy AA, Symons JM (2003). "Nephrotic syndrome in childhood". Lancet. 362 (9384): 629–39. doi:10.1016/S0140-6736(03)14184-0. PMID 12944064.