Sandbox Organ-Based Infections: Difference between revisions
Jump to navigation
Jump to search
Gerald Chi- (talk | contribs) |
Gerald Chi- (talk | contribs) |
||
| Line 49: | Line 49: | ||
====Osteomyelitis, Diabetic foot==== | ====Osteomyelitis, Diabetic foot==== | ||
{{Rx|Chronic Infection or Recent Antibiotic Use}} | {{Rx|Chronic Infection or Recent Antibiotic Use}} | ||
* '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Cefoxitin]]''' 1 g IV q4h (or 2 g IV q6–8h) {{or}} '''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[ | * '''[[Levofloxacin]]''' 750 mg IV/PO q24h {{or}} '''[[Cefoxitin]]''' 1 g IV q4h (or 2 g IV q6–8h) {{or}} '''[[Ceftriaxone]]''' 1–2 g/day IV/IM q12–24h {{or}} '''[[Ampicillin-Sulbactam]]''' 1.5–3 g IV/IM q6h {{or}} '''[[Moxifloxacin]]''' 400 mg IV/PO q24h {{or}} '''[[Ertapenem]]''' 1 g IV/IM q24h {{or}} '''[[Tigecycline]]''' 100 mg IV, then 50 mg IV q12h {{or}} '''[[Imipenem-Cilastatin]]''' 0.5–1 g IV q6–8h | ||
</li> | </li> | ||
{{Rx|High Risk for MRSA}} | {{Rx|High Risk for MRSA}} | ||
* '''[[Linezolid]]''' 600 mg IV/PO q12h {{or}} '''[[Daptomycin]]''' 4 mg/kg IV q24h {{or}} '''[[Vancomycin]]''' 15–20 mg/kg IV q8–12h (trough: 10–20 mg/L) | * '''[[Linezolid]]''' 600 mg IV/PO q12h {{or}} '''[[Daptomycin]]''' 4 mg/kg IV q24h {{or}} '''[[Vancomycin]]''' 15–20 mg/kg IV q8–12h (trough: 10–20 mg/L) | ||
</li> | |||
{{Rx|High Risk for Pseudomonas aeruginosa}} | |||
* '''[[Piperacillin–Tazobactam]]''' 3.375 g IV q6–8h | |||
</li> | |||
{{Rx|Polymicrobial Infection}} | |||
* '''[[Vancomycin]]''' 15–20 mg/kg IV q8–12h (trough: 10–20 mg/L) {{or}} '''[[Linezolid]]''' 600 mg IV/PO q12h {{or}} '''[[Daptomycin]]''' 4 mg/kg IV q24h {{and}} | |||
* '''[[Piperacillin–Tazobactam]]''' 3.375 g IV q6–8h {{or}} '''[[Imipenem-Cilastatin]]''' 0.5–1 g IV q6–8h {{or}} '''[[Ertapenem]]''' 1 g IV/IM q24h {{or}} '''[[Meropenem]]''' 1 g IV/IM q24h {{or2}} | |||
* '''[[Metronidazole]]''' 15 mg/kg IV, then 7.5 mg/kg IV q6h {{and2}} '''[[Ceftazidime]]''' 2 g IV q8h {{or}} '''[[Cefepime]]''' 2 g IV q8h {{or}} '''[[Aztreonam]]''' 2 g IV q6–8h | |||
</li> | </li> | ||
Revision as of 08:49, 9 May 2015
Musculoskeletal
Osteomyelitis
Osteomyelitis, Candidal osteomyelitis
- Fluconazole 400 mg (6 mg/kg) IV/po daily OR Lipid-based Amphotericin B 3-5 mg/kg daily for two weeks, followed by Fluconazole
- Caspofungin 70 mg loading dose, then 50 mg/day IV OR Micafungin 100 mg/day IV or Anidulafungin 200 mg IV loading dose, then 100 mg/day IV
Osteomyelitis, Chronic osteomyelitis
- Systemic antibiotics per culture and susceptibility results AND
- Surgical debridement
Osteomyelitis, Contiguous with vascular insufficiency
- Systemic antibiotics per culture and susceptibility results AND
- Surgical debridement AND
- Revascularization if possible
Osteomyelitis, Contiguous without vascular insufficiency
- Vancomycin 1 gm IV q12h AND
- Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h
- Linezolid 600 mg po/IV bid AND
- Ceftazidime 2 gm IV q8h OR Cefepime 2 gm IV q12h
- Ciprofloxacin 750 mg po bid OR Linezolid 600 mg po/IV bid
- Vancomycin 15-20 mg/kg IV q8-12h targeting trough concentrations of 15-20 mg/L
- Ciprofloxacin 750 mg po bid OR Levofloxacin 750 mg po once daily if susceptible AND
- Rifampin 300-450 mg po bid OR Rifampin 600 mg po once daily if susceptible
Osteomyelitis, Diabetic foot
- Levofloxacin 750 mg IV/PO q24h OR Cefoxitin 1 g IV q4h (or 2 g IV q6–8h) OR Ceftriaxone 1–2 g/day IV/IM q12–24h OR Ampicillin-Sulbactam 1.5–3 g IV/IM q6h OR Moxifloxacin 400 mg IV/PO q24h OR Ertapenem 1 g IV/IM q24h OR Tigecycline 100 mg IV, then 50 mg IV q12h OR Imipenem-Cilastatin 0.5–1 g IV q6–8h
- Linezolid 600 mg IV/PO q12h OR Daptomycin 4 mg/kg IV q24h OR Vancomycin 15–20 mg/kg IV q8–12h (trough: 10–20 mg/L)
- Piperacillin–Tazobactam 3.375 g IV q6–8h
- Vancomycin 15–20 mg/kg IV q8–12h (trough: 10–20 mg/L) OR Linezolid 600 mg IV/PO q12h OR Daptomycin 4 mg/kg IV q24h AND
- Piperacillin–Tazobactam 3.375 g IV q6–8h OR Imipenem-Cilastatin 0.5–1 g IV q6–8h OR Ertapenem 1 g IV/IM q24h OR Meropenem 1 g IV/IM q24h
OR - Metronidazole 15 mg/kg IV, then 7.5 mg/kg IV q6h AND Ceftazidime 2 g IV q8h OR Cefepime 2 g IV q8h OR Aztreonam 2 g IV q6–8h