Febrile neutropenia history and symptoms

For patient information page, see Febrile neutropenia (patient information).

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: F and N; fever and neutropenia; FN; hot and low; hot leuk; neutropenic fever; neutropenic fever syndrome; neutropenic sepsis

Overview

Pertinent history includes prior use of antimicrobial agents, potential infection exposures, previous documented infections or pathogen colonization, catheter or device placement, co-existence of noninfectious causes of fever, and co-morbidities. Symptoms secondary to inflammation are attenuated and fever is often the only clue indicative of an underlying infection.

History

Pertinent history should include new site-specific symptoms, prior use of antimicrobial agents, potential infection exposures, previous documented infections or pathogen colonization, catheter or device placement, and co-existence of noninfectious causes of fever, such as blood product administration. Underlying co-morbidities, such as diabetes, chronic obstructive lung disease, and/or recent procedures, should also be noted.

Signs and Symptoms

In neutropenic patients, manifestations secondary to inflammation are attenuated and fever is often the only clue indicative of an underlying infection.