Histoplasmosis medical therapy: Difference between revisions
Jump to navigation
Jump to search
| Line 14: | Line 14: | ||
:*Acute pulmonary histoplasmosis | :*Acute pulmonary histoplasmosis | ||
::*Moderately severe or severe | ::*Moderately severe or severe | ||
:::*Preferred regimen | :::*Preferred regimen: Lipid amphotericin B (Lipid AmB) 3.0–5.0 mg/kg daily for 1–2 weeks {{or}} [[Amphotericin B]] deoxycholate 0.7–1.0 mg/kg daily for 1–2 weeks, followed by [[Itraconazole]] 200 mg 3 times daily for 3 days and then 200 mg twice daily, for a total of 12 weeks | ||
Note: [[Methylprednisolone]] 0.5–1.0 mg/kg daily intravenously during the first 1–2 weeks of antifungal therapy is recommended for patients who develop respiratory complications, including hypoxemia or significant respiratory distress. | :::*Note: [[Methylprednisolone]] 0.5–1.0 mg/kg daily intravenously during the first 1–2 weeks of antifungal therapy is recommended for patients who develop respiratory complications, including hypoxemia or significant respiratory distress. | ||
==References== | ==References== | ||
Revision as of 18:37, 26 June 2015
|
Histoplasmosis Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Histoplasmosis medical therapy On the Web |
|
American Roentgen Ray Society Images of Histoplasmosis medical therapy |
|
Risk calculators and risk factors for Histoplasmosis medical therapy |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Medical Therapy
Antifungal medications are used to treat severe cases of acute histoplasmosis and all cases of chronic and disseminated disease. Typical treatment of severe disease first involves treatment with amphotericin B, followed by oral itraconazole.[1] In many milder cases, simply itraconazole is sufficient. Asymptomatic disease is typically not treated. Past infection results in partial protection against ill effects if reinfected.
Antimicrobial Regimen
- Histoplasmosis
- Acute pulmonary histoplasmosis
- Moderately severe or severe
- Preferred regimen: Lipid amphotericin B (Lipid AmB) 3.0–5.0 mg/kg daily for 1–2 weeks OR Amphotericin B deoxycholate 0.7–1.0 mg/kg daily for 1–2 weeks, followed by Itraconazole 200 mg 3 times daily for 3 days and then 200 mg twice daily, for a total of 12 weeks
- Note: Methylprednisolone 0.5–1.0 mg/kg daily intravenously during the first 1–2 weeks of antifungal therapy is recommended for patients who develop respiratory complications, including hypoxemia or significant respiratory distress.