Sandbox carlos: Difference between revisions
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{{PBI|Human herpesvirus 8 (KSHV)}} | {{PBI|Human herpesvirus 8 (KSHV)}} | ||
:* 1. '''Mild to moderate Kaposi sarcoma''' | :* 1. '''Mild to moderate Kaposi sarcoma'''<ref>{{ cite web | title = Guidelines for Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents | url = https://aidsinfo.nih.gov/contentfiles/lvguidelines/AdultOITablesOnly.pdf }}</ref> | ||
::* Preferred regimen: initiate or optimize ART | ::* Preferred regimen: initiate or optimize ART | ||
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::* Preferred regimen (3): [[Valganciclovir]] 900 mg PO BID {{and}} [[Zidovudine]] 600 mg PO q6h for 7–21 days | ::* Preferred regimen (3): [[Valganciclovir]] 900 mg PO BID {{and}} [[Zidovudine]] 600 mg PO q6h for 7–21 days | ||
::* Alternative regimen: [[Rituximab]] 375 mg/m2 given weekly for 4–8 weeks (may be an alternative to or used adjunctively with antiviral therapy) | ::* Alternative regimen: [[Rituximab]] 375 mg/m2 given weekly for 4–8 weeks (may be an alternative to or used adjunctively with antiviral therapy) | ||
==References== | |||
{{reflist}} | |||
Revision as of 18:45, 14 July 2015
- Human herpesvirus 8 (KSHV)
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- 1. Mild to moderate Kaposi sarcoma[1]
- Preferred regimen: initiate or optimize ART
- 2. Advanced Kaposi sarcoma (ACTG Stage T1, including disseminated cutaneous or visceral Kaposi sarcoma)
- Preferred regimen: chemotherapy (per oncology consult) AND ART
- 3. Primary effusion lymphoma
- Preferred regimen: chemotherapy (per oncology consult) AND ART
- Note: Valganciclovir PO or Ganciclovir IV can be used as adjunctive therapy.
- 4. Multicentric Castleman's disease
- Preferred regimen (1): Valganciclovir 900 mg PO bid for 3 weeks
- Preferred regimen (2): Ganciclovir 5 mg/kg IV q12h for 3 weeks
- Preferred regimen (3): Valganciclovir 900 mg PO BID AND Zidovudine 600 mg PO q6h for 7–21 days
- Alternative regimen: Rituximab 375 mg/m2 given weekly for 4–8 weeks (may be an alternative to or used adjunctively with antiviral therapy)