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| ::* 2. '''Outpatient treatment'''
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| ::* 2.1 Previously healthy and no risk factors for drug-resistant Streptococcus pneumoniae infection:
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| :::* Preferred regimen:[[Macrolides]] ([[azithromycin]], [[clarithromycin]], {{or}} [[erythromycin]]) (strong recommendation)
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| :::* Alternative regimen: [[Doxycycline]]
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| :::* 2.2 Preferred regimen in presence of comorbidities, such as chronic heart, lung, liver, or renal disease; diabetes mellitus; alcoholism; malignancies; asplenia; immunosuppressing conditions or use of immunosuppressing drugs; use of antimicrobials within the previous 3 months or other risks for drug resistant Streptococcus pneumoniae infection: Option A [[Fluoroquinolone]] ([[moxifloxacin]], [[gemifloxacin]], {{or}} [[levofloxacin]] Option B [[beta-lactam]] {{and}} a [[macrolide]]
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| :::* 2.3 Preferred regimen in regions with a high rate of infection macrolide resistant S. pneumoniae: [[Fluoroquinolone]] ([[moxifloxacin]], [[gemifloxacin]], {{or}} [[levofloxacin]] and [[beta-lactam]] {{and}} a [[macrolide]]
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| ::* 3. '''Inpatient non Intensive care unit treatment'''
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| :::* Preferred regimen:[[fluoroquinolone]]
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| :::* Preferred regimen in level one evidence: [[beta-lactam]] {{and}} [[macrolide]](Preferred [[beta-lactam]] agents include [[cefotaxime]], [[ceftriaxone]], and [[ampicillin]]; [[ertapenem]] for selected patients
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| :::* Preferred regimen in level two evidence: [[beta-lactam]] ([[cefotaxime]], [[ceftriaxone]] {{or}} [[ampicillin-sulbactam]]) {{and}} either [[azithromycin]] {{or}} [[fluoroquinolone]]
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| :::* Preferred regimen in level three evidence: [[doxycycline]] as an alternative to [[macrolide]] {{or}} [[fluoroquinolone]] for [[penicillin allergic patients]]
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| :::* Preferred regimen in Penicillin allergic patients: [[Fluoroquinolone]] {{and}} [[aztreonam]]
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| :::* Preferred regimen for Community acquired methicillin resistant staphylococcus aureus infection: [[vancomycin]] {{or}} [[linezolid]]
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| ::* 3. '''Inpatient Intensive care unit treatment'''
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| ==References== | | ==References== |
| {{reflist}} | | {{reflist}} |