Basal cell carcinoma classification: Difference between revisions
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==Overview== | ==Overview== | ||
The classification of basal cell carcinoma (BCC) | The classification of basal cell carcinoma (BCC) is divided into many clinical variants. | ||
==Basal Cell Carcinoma Classification== | ==Basal Cell Carcinoma Classification== | ||
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| '''Nodular BCC'''||Comprises about 60-80% of cases; most commonly found on the skin of the head; clinically: elevated, exophytic pearl-shaped nodules with | | '''Nodular BCC'''||Comprises about 60-80% of cases; most commonly found on the skin of the head; clinically: elevated, exophytic pearl-shaped nodules with [[telangiectasias]] on the surface and periphery; histologically: nest-like infiltration from basaloid cells | ||
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| '''Cystic BCC'''||≥ 1 cystic node with different sizes located peripherally to the centrally placed tumor nests | | '''Cystic BCC'''||≥ 1 cystic node with different sizes located peripherally to the centrally placed [[tumor]] nests | ||
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| '''Infiltrated BCC'''||Most common found on the upper part of the trunk or face; clinically: whitish, compact, not well-defined plaque; histologically: thin, nest-like bundles of basaloid cells infiltrating in the dermal collagenous fibers | | '''Infiltrated BCC'''||Most common found on the upper part of the trunk or face; clinically: whitish, compact, not well-defined plaque; histologically: thin, nest-like bundles of basaloid cells infiltrating in the dermal [[collagenous]] fibers | ||
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| '''Pigment BCC'''||The color varies from dark brown to black; clinically: nodular, micronodular, multifocal, supercial; histologically: nests of basaloid cells, melanocytes and melanophages, moderate inflammatory infiltrate | | '''Pigment BCC'''||The color varies from dark brown to black; clinically: nodular, micronodular, multifocal, supercial; histologically: nests of basaloid cells, melanocytes and melanophages, moderate [[inflammatory]] infiltrate | ||
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| '''Fibroepithelioma of Pinkus'''||Most commonly on the skin of the back; affects women especially; clinically: elevated pink or erythematous nodules; histologically: trabecular, elongated, and branched thin strands of basaloid cells | | '''Fibroepithelioma of Pinkus'''||Most commonly on the skin of the back; affects women especially; clinically: elevated pink or [[erythematous]] nodules; histologically: trabecular, elongated, and branched thin strands of basaloid cells | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Saarah T. Alkhairy, M.D.
Overview
The classification of basal cell carcinoma (BCC) is divided into many clinical variants.
Basal Cell Carcinoma Classification
The following table summarizes the classification of the clinical variants of basal cell carcinoma (BCC)[1]:
| Clinical Variants | Description |
| Nodular BCC | Comprises about 60-80% of cases; most commonly found on the skin of the head; clinically: elevated, exophytic pearl-shaped nodules with telangiectasias on the surface and periphery; histologically: nest-like infiltration from basaloid cells |
| Cystic BCC | ≥ 1 cystic node with different sizes located peripherally to the centrally placed tumor nests |
| Sclerodermiform (morpheiform) BCC | The tumor cells are surrounded by fibrotic stroma; clinically: infiltrated plaque with a slightly shining surface and not well-defined borders; immunochemistry: expression of smooth muscle alpha-actin |
| Infiltrated BCC | Most common found on the upper part of the trunk or face; clinically: whitish, compact, not well-defined plaque; histologically: thin, nest-like bundles of basaloid cells infiltrating in the dermal collagenous fibers |
| Micronodular BCC | Most commonly found on the skin of the back; clinically: may be flat or elevated; yellow-whitish color when flat, clear outlines and thick at palpation; histologically: small rounded nodules of basaloid cells and minimal palisading |
| Superficial BCC | Comprises about 10-30% of cases; clinically: erythematous squamous plaque with clear borders, pearl-shape edge, superficial erosion, without tendencies for invasive growth; histologically: nests of basaloid cells located subepidermally, connection with the basal layer of the epidermis and no infiltration of tumor cells in the reticular dermis |
| Pigment BCC | The color varies from dark brown to black; clinically: nodular, micronodular, multifocal, supercial; histologically: nests of basaloid cells, melanocytes and melanophages, moderate inflammatory infiltrate |
| Fibroepithelioma of Pinkus | Most commonly on the skin of the back; affects women especially; clinically: elevated pink or erythematous nodules; histologically: trabecular, elongated, and branched thin strands of basaloid cells |
References
- ↑ Dourmishev, LyubomirA; Rusinova, Darena; Botev, Ivan (2013). "Clinical variants, stages, and management of basal cell carcinoma". Indian Dermatology Online Journal. 4 (1): 12. doi:10.4103/2229-5178.105456. ISSN 2229-5178.