Anaplastic large cell lymphoma differential diagnosis: Difference between revisions
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*Other mimics include CD30 positive B-cell lymphomas with anaplastic cells (including Hodgkin lymphomas). These are identified by their positivity for markers of B-cell lineage and frequent presence of markers of EBV. | *Other mimics include CD30 positive B-cell lymphomas with anaplastic cells (including Hodgkin lymphomas). These are identified by their positivity for markers of B-cell lineage and frequent presence of markers of EBV. | ||
*Primary cutaneous T-cell lymphomas may also be positive for CD30; these are excluded by their anatomic distribution. ALK positivity may also be seen in some large cell B-cell lymphomas and occasionally in [[rhabdomyosarcoma]]s. | *Primary cutaneous T-cell lymphomas may also be positive for CD30; these are excluded by their anatomic distribution. ALK positivity may also be seen in some large cell B-cell lymphomas and occasionally in [[rhabdomyosarcoma]]s. | ||
*[[ALCL ALK negative]] | |||
*Primary cutaneous ALCL | |||
*Diffuse large B-cell lymphoma, anaplastic type | |||
*Diffuse large B-cell lymphoma, plasmablastic type | |||
*[[Hodgkin lymphoma]] | |||
==References== | ==References== | ||
Revision as of 20:06, 9 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Differential diagnosis
- As the appearance of the hallmark cells, pattern of growth (nesting within lymph nodes) and positivity for EMA may mimic metastatic carcinoma, it is important to include markers for cytokeratin in any diagnostic panel (these will be negative in the case of anaplastic lymphoma).
- Other mimics include CD30 positive B-cell lymphomas with anaplastic cells (including Hodgkin lymphomas). These are identified by their positivity for markers of B-cell lineage and frequent presence of markers of EBV.
- Primary cutaneous T-cell lymphomas may also be positive for CD30; these are excluded by their anatomic distribution. ALK positivity may also be seen in some large cell B-cell lymphomas and occasionally in rhabdomyosarcomas.
- ALCL ALK negative
- Primary cutaneous ALCL
- Diffuse large B-cell lymphoma, anaplastic type
- Diffuse large B-cell lymphoma, plasmablastic type
- Hodgkin lymphoma