Teratoma classification: Difference between revisions
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==Classification== | ==Classification== | ||
* '''Childhood Extracranial Germ Cell Tumors classification''' | * '''Childhood Extracranial Germ Cell Tumors classification''' | ||
:* 1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.<ref name="pmid6343221">{{cite journal| author=Dehner LP| title=Gonadal and extragonadal germ cell neoplasia of childhood. | journal=Hum Pathol | year= 1983 | volume= 14 | issue= 6 | pages= 493-511 | pmid=6343221 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6343221 }} </ref> | :* 1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.<ref name="pmid6343221">{{cite journal| author=Dehner LP| title=Gonadal and extragonadal germ cell neoplasia of childhood. | journal=Hum Pathol | year= 1983 | volume= 14 | issue= 6 | pages= 493-511 | pmid=6343221 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6343221 }} </ref><ref name="pmid18381640">{{cite journal| author=McIntyre A, Gilbert D, Goddard N, Looijenga L, Shipley J| title=Genes, chromosomes and the development of testicular germ cell tumors of adolescents and adults. | journal=Genes Chromosomes Cancer | year= 2008 | volume= 47 | issue= 7 | pages= 547-57 | pmid=18381640 | doi=10.1002/gcc.20562 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18381640 }} </ref> Childhood extracranial GCTs can be divided into the following two types: | ||
:::* Gonadal. | :::* Gonadal. | ||
:::* Extragonadal. | :::* Extragonadal. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Monalisa Dmello, M.B,B.S., M.D. [2]
Classification
- Childhood Extracranial Germ Cell Tumors classification
- 1. GCTs arise from primordial germ cells, which migrate during embryogenesis from the yolk sac through the mesentery to the gonads.[1][2] Childhood extracranial GCTs can be divided into the following two types:
- Gonadal.
- Extragonadal.
- 2. Most childhood extragonadal GCTs arise in midline sites (i.e., sacrococcygeal, mediastinal, and retroperitoneal); the midline location may represent aberrant embryonic migration of the primordial germ cells.Childhood extracranial GCTs are broadly classified as the following:
- Mature teratomas.
- Immature teratomas.
- Malignant GCTs.
- 3. GCTs comprise a variety of histologic diagnoses and can also be divided into the following histologic types:
- Germinoma.
- Germinoma.
- Dysgerminoma (ovary).
- Seminoma (testis).
- Nongerminoma.
- Teratoma (mature and immature).
- Yolk sac tumor (endodermal sinus tumor).
- Choriocarcinoma.
- Embryonal carcinoma.
- Gonadoblastoma.
- Mixed GCT
- 4. Pediatric GCT Biology
- The following biologically distinct subtypes of GCTs are found in children and adolescents:
- Testicular GCTs.
- Ovarian GCTs.
- Extragonadal extracranial GCTs.
References
- ↑ Dehner LP (1983). "Gonadal and extragonadal germ cell neoplasia of childhood". Hum Pathol. 14 (6): 493–511. PMID 6343221.
- ↑ McIntyre A, Gilbert D, Goddard N, Looijenga L, Shipley J (2008). "Genes, chromosomes and the development of testicular germ cell tumors of adolescents and adults". Genes Chromosomes Cancer. 47 (7): 547–57. doi:10.1002/gcc.20562. PMID 18381640.