Astrocytoma pathophysiology: Difference between revisions
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===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
Histologic diagnosis with tissue biopsy will normally reveal an infiltrative character suggestive of the slow growing nature of the tumor. The tumor may be cavitating, pseudocyst-forming, or noncavitating. Appearance is usually white-gray, firm, and almost indistinguishable from normal white matter. | Histologic diagnosis with [[tissue]] [[biopsy]] will normally reveal an infiltrative character suggestive of the slow growing nature of the [[tumor]]. The tumor may be cavitating, [[pseudocyst]]-forming, or noncavitating. Appearance is usually white-gray, firm, and almost indistinguishable from normal white matter. | ||
==References== | ==References== | ||
Revision as of 20:41, 19 August 2015
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Astrocytoma Microchapters |
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Diagnosis |
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Treatment |
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Case Study |
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Astrocytoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Astrocytoma pathophysiology |
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Risk calculators and risk factors for Astrocytoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Shivali Marketkar, M.B.B.S. [2]
Overview
Well-differentiated astrocytomas constitute about 25 to 30% of cerebral gliomas. They have a predilection for the cerebrum, cerebellum, hypothalamus, pons, and optic nerve and chiasm. Although astrocytomas have many different histological characteristics, the most common type is the well-differentiated fibrillary astrocytoma. These tumors express glial fibrillary acidic protein (GFAP), which possibly functions as a tumor suppressor[1], and is a useful diagnostic marker in a tissue biopsy. [2]
Pathophysiology
Gross Pathology
Microscopic Pathology
Histologic diagnosis with tissue biopsy will normally reveal an infiltrative character suggestive of the slow growing nature of the tumor. The tumor may be cavitating, pseudocyst-forming, or noncavitating. Appearance is usually white-gray, firm, and almost indistinguishable from normal white matter.
References
- ↑ M Toda; et al. (1994). "Cell growth suppression of astrocytoma C6 cells by glial fibrillary acidic protein cDNA transfection". Journal of Neurochemistry. 63 (5): 1975–1978. PMID 7931355.
- ↑ JHN Deck; et al. (1978). "The role of glial fibrillary acidic protein in the diagnosis of central nervous system tumors". Acta Neuropathologica. Springer Berlin / Heidelberg. 42 (3): 183–190. doi:10.1007/BF00690355.