Merkel cell cancer classification: Difference between revisions
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* Small cell: diffuse, few high density granules on ultrasound examination (second most common). | * Small cell: diffuse, few high density granules on ultrasound examination (second most common). | ||
==Staging== | ==Staging== | ||
* According to the [TNM staging system], there are four stages of Merkel cell carcinoma based on the tumor size, presence of lymph nodes and metastasis. Each stage is assigned a letter/number. | |||
* The stages of Merkel cell carcinoma are shown in the table below: | |||
{| {{table}} | {| {{table}} | ||
| align="center" style="background:#f0f0f0;"|'''Stage''' | | align="center" style="background:#f0f0f0;"|'''Stage''' | ||
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| IV||Any size tumor (includes invading tumors)||Any lymph node metastasis||Metastasis beyond regional lymph nodes | | IV||Any size tumor (includes invading tumors)||Any lymph node metastasis||Metastasis beyond regional lymph nodes | ||
|} | |} | ||
==References== | ==References== | ||
Revision as of 13:27, 20 August 2015
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Merkel cell cancer Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Merkel cell cancer classification On the Web |
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American Roentgen Ray Society Images of Merkel cell cancer classification |
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Risk calculators and risk factors for Merkel cell cancer classification |
Classification
Histologically, MCC has been classified into three distinct subtypes:
- Trabecular: classic pattern, large-cell type, high density or granules on ultrasound examination.
- Intermediate: solid pattern (most common).
- Small cell: diffuse, few high density granules on ultrasound examination (second most common).
Staging
- According to the [TNM staging system], there are four stages of Merkel cell carcinoma based on the tumor size, presence of lymph nodes and metastasis. Each stage is assigned a letter/number.
- The stages of Merkel cell carcinoma are shown in the table below:
| Stage | Primary Tumor | Lymph Node | Metastasis |
| 0 | In situ primary tumor | No regional lymph node metastasis | No distant metastasis |
| IA | Less than or equal to 2 cm maximum tumor dimension | Nodes negative by pathologic exam | No distant metastasis |
| IB | Less than or equal to 2 cm maximum tumor dimension | Nodes negative by clinical exam* (no pathologic node exam performed) | No distant metastasis |
| IIA | Greater than 2 cm tumor dimension | Nodes negative by pathologic exam | No distant metastasis |
| IIB | Greater than 2 cm tumor dimension | Nodes negative by clinical exam* (no pathologic node exam performed) | No distant metastasis |
| IIC | Primary tumor invades bone, muscle, fascia, or cartilage | No regional lymph node metastasis | No distant metastasis |
| IIIA | Any size tumor (includes invading tumors) | Micrometastasis** | No distant metastasis |
| IIIB | Any size tumor (includes invading tumors) | "Macrometastasis*** -OR- In transit metastasis****" | No distant metastasis |
| IV | Any size tumor (includes invading tumors) | Any lymph node metastasis | Metastasis beyond regional lymph nodes |