Pancreatic cancer pathophysiology: Difference between revisions
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{{Pancreatic cancer}} | |||
The most common form of pancreatic cancer (adenocarcinoma) is typically characterized by moderately to [[Anaplasia|poorly differentiated]] glandular structures on microscopic examination. There is typically considerable [[desmoplasia]] or formation of a dense fibrous [[Stroma (animal tissue)|stroma]] or structural tissue consisting of a range of [[cell type]]s (including [[myofibroblast]]s, [[macrophage]]s, [[lymphocyte]]s and [[mast cell]]s) and deposited material (such as [[type I collagen]] and [[hyaluronic acid]]). This creates a [[tumor microenvironment]] that is short of [[blood vessel]]s (hypovascular) and so of [[oxygen]] ([[tumor hypoxia]]). | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
Revision as of 17:04, 20 August 2015
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
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The most common form of pancreatic cancer (adenocarcinoma) is typically characterized by moderately to poorly differentiated glandular structures on microscopic examination. There is typically considerable desmoplasia or formation of a dense fibrous stroma or structural tissue consisting of a range of cell types (including myofibroblasts, macrophages, lymphocytes and mast cells) and deposited material (such as type I collagen and hyaluronic acid). This creates a tumor microenvironment that is short of blood vessels (hypovascular) and so of oxygen (tumor hypoxia).