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*Cytokeratin-20 immunohistochemical staining is required for the histopathological diagnosis of Merkel cell cancer. | *Cytokeratin-20 immunohistochemical staining is required for the histopathological diagnosis of Merkel cell cancer. | ||
*On biopsy, Merkel cell cancer is often characterized by the following findings:<ref name="pmid18280333">{{cite journal| author=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF et al.| title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. | journal=J Am Acad Dermatol | year= 2008 | volume= 58 | issue= 3 | pages= 375-81 | pmid=18280333 | doi=10.1016/j.jaad.2007.11.020 | pmc=PMC2335370 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18280333 }} </ref> | *On biopsy, Merkel cell cancer is often characterized by the following findings:<ref name="pmid18280333">{{cite journal| author=Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF et al.| title=Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. | journal=J Am Acad Dermatol | year= 2008 | volume= 58 | issue= 3 | pages= 375-81 | pmid=18280333 | doi=10.1016/j.jaad.2007.11.020 | pmc=PMC2335370 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18280333 }} </ref> | ||
:*Neurosecretory | :*Neurosecretory granule s within cytoplasmic extensions | ||
:*Positive staining for cytokeratin-20 immunohistochemical assay | :*Positive staining for [[Keratin 20|cytokeratin-20]] immunohistochemical assay | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 19:44, 20 August 2015
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Merkel cell cancer Microchapters |
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Merkel cell cancer other diagnostic studies On the Web |
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American Roentgen Ray Society Images of Merkel cell cancer other diagnostic studies |
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Risk calculators and risk factors for Merkel cell cancer other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
On biopsy, Merkel cell cancer is characterized by the presence of neurosecretory granules within cytoplasmic extensions and positivity on cytokeratin-20 immunohistochemical staining.
Biopsy
- Skin biopsy is required for the diagnosis of Merkel cell cancer.
- The histopathological diagnosis of Merkel cell tumor is difficult, and the majority of cases with Merkel cell cancer are often misdiagnosed.
- Cytokeratin-20 immunohistochemical staining is required for the histopathological diagnosis of Merkel cell cancer.
- On biopsy, Merkel cell cancer is often characterized by the following findings:[1]
- Neurosecretory granule s within cytoplasmic extensions
- Positive staining for cytokeratin-20 immunohistochemical assay
References
- ↑ Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF; et al. (2008). "Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features". J Am Acad Dermatol. 58 (3): 375–81. doi:10.1016/j.jaad.2007.11.020. PMC 2335370. PMID 18280333.