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Diffuse large B-cell lymphoma encompasses a biologically and clinically diverse set of diseases,<ref name="Alizadeh2000">{{cite journal |doi=10.1038/35000501 |pmid=10676951 |title=Distinct types of diffuse large B-cell lymphoma identified by gene expression | Diffuse large B-cell lymphoma encompasses a biologically and clinically diverse set of diseases,<ref name="Alizadeh2000">{{cite journal |doi=10.1038/35000501 |pmid=10676951 |title=Distinct types of diffuse large B-cell lymphoma identified by gene expression | ||
profiling |journal=Nature |volume=403 |issue=6769 |pages=503–11 |year=2000 |last1=Alizadeh |first1=Ash A. |last2=Eisen |first2=Michael B. |last3=Davis |first3=R. Eric |last4=Ma |first4=Chi |last5=Lossos |first5=Izidore S. |last6=Rosenwald |first6=Andreas |last7=Boldrick |first7=Jennifer C. |last8=Sabet |first8=Hajeer |last9=Tran |first9=Truc |last10=Yu |first10=Xin |last11=Powell |first11=John I. |last12=Yang |first12=Liming |last13=Marti |first13=Gerald E. |last14=Moore |first14=Troy |last15=Hudson |first15=James |last16=Lu |first16=Lisheng |last17=Lewis |first17=David B. |last18=Tibshirani |first18=Robert |last19=Sherlock |first19=Gavin |last20=Chan |first20=Wing C. |last21=Greiner |first21=Timothy C. |last22=Weisenburger |first22=Dennis D. |last23=Armitage |first23=James O. |last24=Warnke |first24=Roger |last25=Levy |first25=Ronald |last26=Wilson |first26=Wyndham |last27=Grever |first27=Michael R. |last28=Byrd |first28=John C. |last29=Botstein |first29=David |last30=Brown |first30=Patrick O. |display-authors=29 |bibcode=2000Natur.403..503A }}</ref> many of which cannot be separated from one another by well-defined and widely accepted criteria. | profiling |journal=Nature |volume=403 |issue=6769 |pages=503–11 |year=2000 |last1=Alizadeh |first1=Ash A. |last2=Eisen |first2=Michael B. |last3=Davis |first3=R. Eric |last4=Ma |first4=Chi |last5=Lossos |first5=Izidore S. |last6=Rosenwald |first6=Andreas |last7=Boldrick |first7=Jennifer C. |last8=Sabet |first8=Hajeer |last9=Tran |first9=Truc |last10=Yu |first10=Xin |last11=Powell |first11=John I. |last12=Yang |first12=Liming |last13=Marti |first13=Gerald E. |last14=Moore |first14=Troy |last15=Hudson |first15=James |last16=Lu |first16=Lisheng |last17=Lewis |first17=David B. |last18=Tibshirani |first18=Robert |last19=Sherlock |first19=Gavin |last20=Chan |first20=Wing C. |last21=Greiner |first21=Timothy C. |last22=Weisenburger |first22=Dennis D. |last23=Armitage |first23=James O. |last24=Warnke |first24=Roger |last25=Levy |first25=Ronald |last26=Wilson |first26=Wyndham |last27=Grever |first27=Michael R. |last28=Byrd |first28=John C. |last29=Botstein |first29=David |last30=Brown |first30=Patrick O. |display-authors=29 |bibcode=2000Natur.403..503A }}</ref> many of which cannot be separated from one another by well-defined and widely accepted criteria. | ||
The [[World Health Organization]] (WHO) classification system defines more than a dozen subtypes, each of which can be differentiated based on the | The [[World Health Organization]] (WHO) classification system defines more than a dozen subtypes, each of which can be differentiated based on the | ||
*Location of the | *Location of the tumor | ||
*Presence of other cells within the | *Presence of other cells within the tumor (such as [[T cell]]s) | ||
*Other illnesses related to Diffuse large B-cell lymphoma. | *Other illnesses related to Diffuse large B-cell lymphoma. | ||
:*One of these well-defined groupings of particular note is Primary mediastinal B-cell lymphoma, which arises within the [[thymus]] or mediastinal lymph nodes. | :*One of these well-defined groupings of particular note is Primary mediastinal B-cell lymphoma, which arises within the [[thymus]] or mediastinal lymph nodes. | ||
B-cell lymphoma, unclassifiable | |||
*Tumor may share many features intermediate between Diffuse large B-cell lymphoma and [[Burkitt lymphoma]]. | |||
*Tumor may share many features intermediate between Diffuse large B-cell lymphoma and Hodgkin’s lymphoma. | |||
Diffuse large B-cell lymphoma, not otherwise specified | |||
*When a case of Diffuse large B-cell lymphoma does not conform to any of the well-defined subtypes, and is also not considered unclassifiable. | |||
*The majority of Diffuse large B-cell lymphoma cases fall into this category. | |||
*Much research has been devoted to separating this still-heterogeneous group; such distinctions are usually made along lines of | |||
:*[[Morphology (biology)|cellular morphology]] | :*[[Morphology (biology)|cellular morphology]] | ||
:*[[gene expression]] | :*[[gene expression]] | ||
:*[[Immunohistochemistry|immunohistochemical]] properties. | :*[[Immunohistochemistry|immunohistochemical]] properties. | ||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 04:34, 21 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Classification
Diffuse large B-cell lymphoma encompasses a biologically and clinically diverse set of diseases,[1] many of which cannot be separated from one another by well-defined and widely accepted criteria.
The World Health Organization (WHO) classification system defines more than a dozen subtypes, each of which can be differentiated based on the
- Location of the tumor
- Presence of other cells within the tumor (such as T cells)
- Other illnesses related to Diffuse large B-cell lymphoma.
- One of these well-defined groupings of particular note is Primary mediastinal B-cell lymphoma, which arises within the thymus or mediastinal lymph nodes.
B-cell lymphoma, unclassifiable
- Tumor may share many features intermediate between Diffuse large B-cell lymphoma and Burkitt lymphoma.
- Tumor may share many features intermediate between Diffuse large B-cell lymphoma and Hodgkin’s lymphoma.
Diffuse large B-cell lymphoma, not otherwise specified
- When a case of Diffuse large B-cell lymphoma does not conform to any of the well-defined subtypes, and is also not considered unclassifiable.
- The majority of Diffuse large B-cell lymphoma cases fall into this category.
- Much research has been devoted to separating this still-heterogeneous group; such distinctions are usually made along lines of
- cellular morphology
- gene expression
- immunohistochemical properties.
References
- ↑ Alizadeh, Ash A.; Eisen, Michael B.; Davis, R. Eric; Ma, Chi; Lossos, Izidore S.; Rosenwald, Andreas; Boldrick, Jennifer C.; Sabet, Hajeer; Tran, Truc; Yu, Xin; Powell, John I.; Yang, Liming; Marti, Gerald E.; Moore, Troy; Hudson, James; Lu, Lisheng; Lewis, David B.; Tibshirani, Robert; Sherlock, Gavin; Chan, Wing C.; Greiner, Timothy C.; Weisenburger, Dennis D.; Armitage, James O.; Warnke, Roger; Levy, Ronald; Wilson, Wyndham; Grever, Michael R.; Byrd, John C.; Botstein, David; et al. (2000). "Distinct types of diffuse large B-cell lymphoma identified by gene expression
profiling". Nature. 403 (6769): 503–11. Bibcode:2000Natur.403..503A. doi:10.1038/35000501. PMID 10676951. line feed character in
|title=at position 78 (help)