Glucagonoma medical therapy: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Glucagonoma}} | {{Glucagonoma}} | ||
{{CMG}} | {{CMG}}{{AE}}{{PSD}} | ||
==Overview== | ==Overview== | ||
The predominant therapy for glucagonoma is surgical resection. Adjunctive chemotherapy may be required. | |||
==Medical Therapy== | ==Medical Therapy== | ||
* Heightened glucagon secretion can be treated with the administration of [[Somatostatin|octreotide, a somatostatin analog]], which inhibits the release of glucagon.<ref>{{cite journal |author=Moattari AR, Cho K, Vinik AI |title=Somatostatin analogue in treatment of coexisting glucagonoma and pancreatic pseudocyst: dissociation of responses |journal=Surgery |volume=108 |issue=3 |pages=581-7 |year=1990 |pmid=2168587 |doi=}}</ref> | * Heightened glucagon secretion can be treated with the administration of [[Somatostatin|octreotide, a somatostatin analog]], which inhibits the release of glucagon.<ref>{{cite journal |author=Moattari AR, Cho K, Vinik AI |title=Somatostatin analogue in treatment of coexisting glucagonoma and pancreatic pseudocyst: dissociation of responses |journal=Surgery |volume=108 |issue=3 |pages=581-7 |year=1990 |pmid=2168587 |doi=}}</ref> | ||
Revision as of 13:44, 14 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2]
Overview
The predominant therapy for glucagonoma is surgical resection. Adjunctive chemotherapy may be required.
Medical Therapy
- Heightened glucagon secretion can be treated with the administration of octreotide, a somatostatin analog, which inhibits the release of glucagon.[1]
- Doxorubicin and streptozotocin have also been used successfully to selectively damage alpha cells of the pancreatic islets. These do not destroy the tumor, but help to minimize progression of symptoms.
- The only curative therapy for glucagonoma is surgical resection, where the tumor is removed. Resection has been known to reverse symptoms in some patients.