Melanoma causes: Difference between revisions
Jump to navigation
Jump to search
YazanDaaboul (talk | contribs) No edit summary |
YazanDaaboul (talk | contribs) No edit summary |
||
| Line 3: | Line 3: | ||
{{CMG}} {{AE}} {{YD}} | {{CMG}} {{AE}} {{YD}} | ||
==Overview== | ==Overview== | ||
Melanoma may be caused by either sporadic genetic mutations (e.g. ''BRAF'' and/or ''N-RAS'') or familial diseases. | Melanoma may be caused by either sporadic genetic mutations (e.g. ''[[BRAF]]'' and/or ''[[Ras|N-RAS]]'') or familial diseases. | ||
==Causes== | ==Causes== | ||
Melanoma may be caused by either sporadic genetic mutations (e.g. ''BRAF'' and/or ''N-RAS'') or familial diseases. | Melanoma may be caused by either sporadic genetic mutations (e.g. ''[[BRAF]]'' and/or ''[[Ras|N-RAS]]'') or familial diseases. | ||
===Sporadic Melanooma=== | ===Sporadic Melanooma=== | ||
*The majority of cases of melanoma are sporadic (90%). | *The majority of cases of melanoma are sporadic (90%). | ||
| Line 12: | Line 12: | ||
===Familial Melanoma=== | ===Familial Melanoma=== | ||
Melanoma may be caused by hereditary diseases (10%) and is associated with mutations of the ''CDKN2A'' gene: | Melanoma may be caused by hereditary diseases (10%) and is associated with mutations of the ''CDKN2A'' gene: | ||
*Familial atypical multiple | *Familial atypical multiple mole melanoma syndrome (FAMMM syndrome) | ||
*Melanoma-astrocytoma syndrome | *Melanoma-astrocytoma syndrome | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 23:17, 21 August 2015
|
Melanoma Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Melanoma causes On the Web |
|
American Roentgen Ray Society Images of Melanoma causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Yazan Daaboul, M.D.
Overview
Melanoma may be caused by either sporadic genetic mutations (e.g. BRAF and/or N-RAS) or familial diseases.
Causes
Melanoma may be caused by either sporadic genetic mutations (e.g. BRAF and/or N-RAS) or familial diseases.
Sporadic Melanooma
- The majority of cases of melanoma are sporadic (90%).
- Melanoma is caused by multiple genetic mutations.
- The most common mutations that result in the development of melanoma are BRAF (approximately 50% of melanomas) and N-RAS (approximately 15% of melanomas).
Familial Melanoma
Melanoma may be caused by hereditary diseases (10%) and is associated with mutations of the CDKN2A gene:
- Familial atypical multiple mole melanoma syndrome (FAMMM syndrome)
- Melanoma-astrocytoma syndrome