Ependymoma pathophysiology: Difference between revisions
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{{Ependymoma}} | {{Ependymoma}} | ||
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==Overview== | ==Overview== | ||
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===Gross Pathology=== | ===Gross Pathology=== | ||
*Ependymomas develop from cells that line the [[brain]] ventricles and [[spinal canal]]. | |||
*They are well-encapsulated tumors and usually arise from the floor of the [[fourth ventricle]], situated in the lower back portion of the brain. | |||
The | *The subependymomas, variant of the ependymoma, arise in the fourth ventricle but may occur in the [[septum pellucidum]] and the cervical spinal cord. | ||
===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Rare diseases]] | [[Category:Rare diseases]] | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 14:45, 6 October 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Pathophysiology
Gross Pathology
- Ependymomas develop from cells that line the brain ventricles and spinal canal.
- They are well-encapsulated tumors and usually arise from the floor of the fourth ventricle, situated in the lower back portion of the brain.
- The subependymomas, variant of the ependymoma, arise in the fourth ventricle but may occur in the septum pellucidum and the cervical spinal cord.
Microscopic Pathology
Ependymomas are composed of cells with regular, round to oval nuclei. There is a variably dense fibrillary background. Tumor cells may form gland-like round or elongated structures that resemble the embryologic ependymal canal, with long, delicate processes extending into the lumen; more frequently present are perivascular pseudorosettes in which tumor cells are arranged around vessels with an intervening zone consisting of thin ependymal processes directed toward the wall of the vessel.[1]. Ependymal rosettes are rare but pathognomonic feature.
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Associated Conditions
The subependymal giant-cell astrocytoma, also called giant-cell glioma, is typically associated with tuberous sclerosis but can occur independent of that condition.
References
- ↑ Kumar, et al. (2005). The Central Nervous System. Pathologic Basis of Disease. 7th Edition. Philadelphia: Elsevier Saunders.