Craniopharyngioma natural history, complication and prognosis: Difference between revisions
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A large percentage of patients have long-term hormone, vision, and nervous system problems after craniopharyngioma is treated. When the tumor is not completely removed, the condition may recur.<ref>Complications of Craniopharyngioma. National library of medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm</ref> | A large percentage of patients have long-term hormone, vision, and nervous system problems after craniopharyngioma is treated. When the tumor is not completely removed, the condition may recur.<ref>Complications of Craniopharyngioma. National library of medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm</ref> | ||
There are complications caused by the radical surgical treatment of craniopharyngioma: | There are complications caused by the ''radical surgical treatment'' of craniopharyngioma: | ||
*Obesity, which can be life-threatening. | *Obesity, which can be life-threatening. Hypothalamic-sparing surgical techniques may result in reduced postoperative obesity without an increase in tumor recurrence | ||
*Hormone replacement therapy | *Hormone replacement therapy | ||
*Severe behavioral problems | *Severe behavioral problems | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Natural History
Complications
A large percentage of patients have long-term hormone, vision, and nervous system problems after craniopharyngioma is treated. When the tumor is not completely removed, the condition may recur.[1]
There are complications caused by the radical surgical treatment of craniopharyngioma:
- Obesity, which can be life-threatening. Hypothalamic-sparing surgical techniques may result in reduced postoperative obesity without an increase in tumor recurrence
- Hormone replacement therapy
- Severe behavioral problems
- Blindness
- Seizures
- Spinal fluid leak
- False aneurysms
- Difficulty with eye movements
- Death from intraoperative hemorrhage, hypothalamic damage, or stroke (rare)
Prognosis
Since craniopharyngioma is a benign tumor, the 5-year and 10-year survival rates, regardless of treatment given, are higher than 90%. The prognosis is very good.[2]. Patients can have a permanent cure if the tumor can be completely removed with surgery or treated with high doses of radiation. If the tumor returns, it will usually come back within the first 2 years after surgery.[3] The outlook depends on:
- Whether or not the tumor can be removed by surgery.
- The neurological deficits and hormonal imbalances caused by the tumor and the treatment
- The patient’s general health
Recent research[4] has demonstrated a malignant (but rare) tendency of craniopharyngiomas. These malignant craniopharyngiomas are very rare, but are associated with poor prognosis.
References
- ↑ Complications of Craniopharyngioma. National library of medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm
- ↑ Prognosis of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc
- ↑ Prognosis. National Library of Medicine. https://www.nlm.nih.gov/medlineplus/ency/article/000345.htm
- ↑ Sofela, AA; Hettige, S; Curran, O; Bassi, S (Sep 2014). "Malignant transformation in craniopharyngiomas". Neurosurgery. 75 (3): 306–14, discussion 314. doi:10.1227/NEU.0000000000000380. PMID 24978859.