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| {{Craniopharyngioma}}
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| {{CMG}}{{AE}}{{SR}}
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| ==Overview==
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| ==Classification==
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| Craniopharyngiomas are believed to derive from Rathke cleft rather than [[squamous cell]] rests along the craniopharyngeal duct as was previously thought. Craniopharyngiomas are classified according to their histologic appearance. The histological appearances of the three pathological subtypes are different, accounting for the different ''imaging features''.These are said to differ not only in appearances, but also in prognosis and epidemiology.<ref>Histologic classification of Craniopharyngioma. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/craniopharyngioma</ref><ref>Classification of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc</ref>
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| *'''Adamantinomatous'''
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| **This type is seen predominantly in '''''children'''''
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| **It consists of reticular epithelial cells which have appearances reminiscent of the [[enamel]] pulp of developing teeth
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| **There may be single or multiple [[cysts]] filled with thick oily fluid high in protein, blood products, and/or cholesterol, creating the so called "machinery oil"
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| **"Wet [[keratin]] nodules" are a characteristic histological feature
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| **Calcification is usually present: 90%
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| **''More'' locally aggressive
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| **''Higher'' rate of recurrence
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| **Activating ''beta-catenin'' gene mutations are found in adamantinomatous tumors
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| *'''Papillary'''
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| **The papillary subtype is seen almost exclusively in '''''adults'''''
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| **It is formed of masses of metaplastic squamous cells
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| **"Wet [[keratin]]" nodule is absent
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| **''Cysts'' do form, but these are less of a feature, and the tumor is more ''solid''
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| **Calcification is uncommon or even rare
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| **''Less'' locally aggressive
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| **''Lower'' rate of recurrence
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| **''BRAF'' V600E [[mutation]]s are observed in [[papillary]] craniopharyngiomas
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| *'''Mixed'''
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| **15%, but shares imaging features and prognosis similar to ''adamantinomatous''
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| ==References==
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| {{Reflist|2}}
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| [[Category:Disease]]
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| [[Category:Types of cancer]]
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| [[Category:Neurology]]
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| [[Category:Neurosurgery]]
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