Linitis plastica laboratory tests: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Linitis plastica}} | {{Linitis plastica}} | ||
{{CMG}}{{AE}} {{STM}} | |||
==Overview== | |||
Laboratory findings consistent with the diagnosis of linitis plastica include abnormal thickening of the submucosal layer of the gastric wall on an endoscopic ultrasound and histopathologic evidence of signet-ring cells and fibrous stroma on gastric biopsies. | |||
==Laboratory findings== | |||
*Complete blood count (CBC) | |||
*Complete metabolic panel (CMP) | |||
*Esophagogastroduodenoscopy with multiple deep biopsies | |||
**Mucosa may look innocent or show superficial ulcerations as in gastritis. | |||
**Histopathologic specimens show poorly differentiated, atypical [[signet ring cell]]s diffusely infiltrating the stomach wall, submucosal fibrosis and thickening.<ref name="SchauerPeiper2011">{{cite journal|last1=Schauer|first1=M|last2=Peiper|first2=M|last3=Theisen|first3=J|last4=Knoefel|first4=W|title=Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment|journal=European Journal of Medical Research|volume=16|issue=1|year=2011|pages=29|issn=2047-783X|doi=10.1186/2047-783X-16-1-29}}</ref><ref>Stomach cancer. Wikipedia. https://en.wikipedia.org/wiki/Stomach_cancer Accessed on November 19, 2015.</ref> | |||
*Upper gastrointestinal endoscopic ultrasound | |||
**A very useful test that helps both in the diagnosis and to know the depth of the tumor invasion. | |||
**A 10-20mm thickening of the submucosal layer is usually present. | |||
*Chest x-ray | |||
**To rule out metastasis | |||
*CT and MRI of chest, abdomen and pelvis | |||
**To know the local invasion and distant metastasis (included as part of staging the disease) | |||
==References== | ==References== | ||
Revision as of 20:28, 8 December 2015
|
Linitis plastica Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Linitis plastica laboratory tests On the Web |
|
American Roentgen Ray Society Images of Linitis plastica laboratory tests |
|
Risk calculators and risk factors for Linitis plastica laboratory tests |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
Laboratory findings consistent with the diagnosis of linitis plastica include abnormal thickening of the submucosal layer of the gastric wall on an endoscopic ultrasound and histopathologic evidence of signet-ring cells and fibrous stroma on gastric biopsies.
Laboratory findings
- Complete blood count (CBC)
- Complete metabolic panel (CMP)
- Esophagogastroduodenoscopy with multiple deep biopsies
- Mucosa may look innocent or show superficial ulcerations as in gastritis.
- Histopathologic specimens show poorly differentiated, atypical signet ring cells diffusely infiltrating the stomach wall, submucosal fibrosis and thickening.[1][2]
- Upper gastrointestinal endoscopic ultrasound
- A very useful test that helps both in the diagnosis and to know the depth of the tumor invasion.
- A 10-20mm thickening of the submucosal layer is usually present.
- Chest x-ray
- To rule out metastasis
- CT and MRI of chest, abdomen and pelvis
- To know the local invasion and distant metastasis (included as part of staging the disease)
References
- ↑ Schauer, M; Peiper, M; Theisen, J; Knoefel, W (2011). "Prognostic factors in patients with diffuse type gastric cancer (linitis plastica) after operative treatment". European Journal of Medical Research. 16 (1): 29. doi:10.1186/2047-783X-16-1-29. ISSN 2047-783X.
- ↑ Stomach cancer. Wikipedia. https://en.wikipedia.org/wiki/Stomach_cancer Accessed on November 19, 2015.