Craniopharyngioma medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
The predominant therapy for craniopharyngioma is surgical resection. Adjunctive chemotherapy and radiation may be required. Subcutaneous pegylated [[interferon]] alpha-2b has been used to treat cystic recurrences. It can also be treated with intracavitary instillation of radioactive P-32, [[bleomycin]] or [[interferon-alpha]] via [[stereotactic]] delivery or placement of an Ommaya catheter. [[Paclitaxel]] and [[carboplatin]] have shown to prevent recurrence of malignant craniopharyngiomas. | The predominant therapy for craniopharyngioma is surgical resection. Adjunctive [[chemotherapy]] and [[radiation]] may be required. Subcutaneous pegylated [[interferon]] alpha-2b has been used to treat cystic recurrences. It can also be treated with intracavitary instillation of radioactive P-32, [[bleomycin]] or [[interferon-alpha]] via [[stereotactic]] delivery or placement of an Ommaya catheter. [[Paclitaxel]] and [[carboplatin]] have shown to prevent recurrence of malignant craniopharyngiomas. | ||
==Medical Therapy== | ==Medical Therapy== | ||
*Although the mainstay of therapy for craniopharyngioma is surgery with or without radiation, there are certain indications for medical therapy as well, mostly in treating recurrent tumors. | *Although the mainstay of therapy for craniopharyngioma is surgery with or without radiation, there are certain indications for medical therapy as well, mostly in treating recurrent tumors. | ||
Revision as of 20:45, 24 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
The predominant therapy for craniopharyngioma is surgical resection. Adjunctive chemotherapy and radiation may be required. Subcutaneous pegylated interferon alpha-2b has been used to treat cystic recurrences. It can also be treated with intracavitary instillation of radioactive P-32, bleomycin or interferon-alpha via stereotactic delivery or placement of an Ommaya catheter. Paclitaxel and carboplatin have shown to prevent recurrence of malignant craniopharyngiomas.
Medical Therapy
- Although the mainstay of therapy for craniopharyngioma is surgery with or without radiation, there are certain indications for medical therapy as well, mostly in treating recurrent tumors.
- Although systemic therapy is generally not utilized, it has been shown that the use of subcutaneous pegylated interferon alpha-2b to manage cystic recurrences can result in durable responses.[1]
- The chemotherapy drugs Paclitaxel and Carboplatin have shown a clinical (but not statistical) significance in increasing the survival rate in patients who've had gross total resections of their malignant tumors.
- Cystic recurrences may be treated with intracavitary instillation of varying agents via stereotactic delivery or placement of an Ommaya catheter. These agents have included radioactive P-32 or other radioactive compounds, bleomycin or interferon-alpha. These strategies have been found to be useful in certain cases, and a low risk of complications has been reported. However, none of these approaches have shown efficacy against solid portions of the tumor.[2]
- The following is an example of a national and/or institutional phase II clinical trial that is currently being conducted. PBTC-039 (NCT01964300) (Peginterferon Alpha-2b) in treating younger patients with craniopharyngioma that is recurrent or cannot be removed by surgery.[3]
References
- ↑ Rx of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc
- ↑ Rx of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc
- ↑ Rx of Craniopharyngioma. Cancer gov. http://www.cancer.gov/types/brain/hp/child-cranio-treatment-pdq#link/_40_toc