Adrenocortical carcinoma history and symptoms: Difference between revisions
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:*[[Amenorrhea|Cessation of menstruation]]. | :*[[Amenorrhea|Cessation of menstruation]]. | ||
3-[[Mineralcorticoid]] excess symptoms include: | |||
* [[ | :*[[Headache]] | ||
:*[[Muscle weakness]] | |||
:*[[Confusion]] | |||
:*[[Palpitations]] | |||
*[[Estrogen]] excess symptoms include: is most readily noted in men, and includes | |||
:*[[Gynecomastia|breast enlargement]] | |||
:*Decreased [[libido]] | |||
:*[[Impotence]].<ref>Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL. ''Harrison's Principles of Internal Medicine''. New York: McGraw-Hill, 2005. ISBN 0-07-139140-1</ref> | |||
==References== | ==References== |
Revision as of 19:28, 25 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]Ahmad Al Maradni, M.D. [3]
Overview
History
Common symptoms
History and Symptoms
Adrenocortical carcinoma may present differently in children and adults. Most tumors in children are functional, and virilization is by far the most common presenting symptom, followed by Cushing's syndrome and precocious puberty. Among adults presenting with hormonal syndromes, Cushing's syndrome alone is most common, followed by mixed Cushing's and virilization (glucocorticoid and androgen overproduction). Feminization and Conn syndrome (mineralcorticoid excess) occur in less than 10% of cases. Rarely, pheochromocytoma-like hypersecretion of catecholamines has been reported in adrenocortical cancers.[1] Non-functional tumors (about 40%, authorities vary) usually present with abdominal or flank pain, or they may be asymptomatic and detected incidentally.
All patients with suspected adrenocortical carcinoma should be carefully evaluated for signs and symptoms of hormonal syndromes. This may include the followings:
1- Glucocorticoid excess symptoms include:
- Weight gain
- Muscle wasting
- Purple lines on the abdomen
- Buffalo hump
- "moonlike" face
- Thin, fragile skin.
2-Androgen excess symptoms include:
- excess facial and body hair most obvious in women
- Acne
- Clitoromegaly
- Deepening of the voice
- Coarsening of facial features
- Cessation of menstruation.
3-Mineralcorticoid excess symptoms include:
- Estrogen excess symptoms include: is most readily noted in men, and includes
- breast enlargement
- Decreased libido
- Impotence.[2]
References
- ↑ Richard Cote, Saul Suster, Lawrence Weiss, Noel Weidner (Editor). Modern Surgical Pathology (2 Volume Set). London: W B Saunders. ISBN 0-7216-7253-1.
- ↑ Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL. Harrison's Principles of Internal Medicine. New York: McGraw-Hill, 2005. ISBN 0-07-139140-1