Ovarian cancer pathophysiology: Difference between revisions

Jump to navigation Jump to search
← Older editNewer edit →
VisualWikitext
Jyostna Chouturi (talk | contribs)
nocaptcha
9,554 edits
No edit summary
Monalisa Dmello (talk | contribs)
CMEUser, nocaptcha
4,359 edits
No edit summary
Line 14: Line 14:
</gallery>
</gallery>
</div>
</div>
==Gross Patholgy==
{| {{table}}
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|''' Vulvar Carcinomas Subtype'''}}
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|'''Features on Gross Pathology'''}}
|-
| Squamous cell carcinoma of vulva||
* Most lesions originate in the labia, primarily the [[labia majora]]. Other areas affected are the [[clitoris]], [[fourchette]], and the local glands
* Unifocal
|-
|Basal cell carcinoma of vulva||
* Pearly nodule with telangiectasias
|-
| Vulvar melanoma||
* Superficial spreading is the most common type
* Brown/black color, but may include reddish brown or white
* Hyperkeratotic, diffused borders with no distinct demarcation
* Irregular and elevated
|-
|}
==Microscopic Pathology==
Histologic subtypes of vulvar cancer include:<ref>{{cite book | last = Hoffman | first = Barbara | title = Williams gynecology | publisher = McGraw-Hill Medical | location = New York | year = 2012 | isbn = 9780071716727 }}</ref><ref> Malignant melanoma. Libre pathology. http://librepathology.org/wiki/index.php/Malignant_melanoma. URL Accessed on September 30, 2015</ref><ref> Basal cell carcinoma
. Libre pathology. http://librepathology.org/wiki/index.php/Basal_cell_carcinoma. URL Accessed on September 30, 2015</ref><ref> Squamous cell carcinoma. Libre pathology. http://librepathology.org/wiki/index.php/Squamous_cell_carcinoma. URL Accessed on September 30, 2015</ref>
*Vulvar carcinomas
:* [[Squamous cell carcinoma]]
:* [[Basal cell carcinoma]]
:* Vulvar [[Paget disease]]
:* Adenocarcinoma
:* Transitional cell carcinoma
:* Verrucous carcinoma
:* Merkel cell tumors
*Vulvar [[malignant melanoma]]
*Vulvar [[sarcoma]]
:* [[Leiomyosarcoma]]
:* Malignant fibrous histiocytoma
:* Epithelial sarcoma
{| {{table}}
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|''' Vulvar Carcinomas Subtype'''}}
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|'''Features on Histopathological Microscopic Analysis'''}}
| align="center" style="background: #4479BA;" | {{fontcolor|#FFF|'''Image'''}}
|-
|-
| Squamous cell carcinoma of vulva||
* Eosinophilia
* Extra large nuclei/bizarre nuclei
* Inflammation (lymphocytes, plasma cells)
* Long rete ridges
* Numerous beeds/blobs of epithelial cells that seem unlikely to be rete ridges
| [[File:Scc.jpg|thumb|none|300px|Squamous cell carcinoma of vulva]]
|-
|Basal cell carcinoma of vulva||
* Basaloid cells - similar in appearance to basal cells
* Moderate blue/grey cytoplasm.
* Dark ovoid/ellipsoid nucleus with uniform chromatin
* Palisading of cells at the edge of the cell nests
* Artefactual separation of cells (forming the nests) from the underlying stroma - key feature
* Surrounded by blue (myxoid) stroma - key feature
| [[File:BCC.jpg|thumb|none|300px|Basal cell carcinoma of vulva]]
|-
| Vulvar melanoma||
* Presence of intraepidermal lateral spread (most characteristic feature)
* Dermal invasion
* Desmoplasia
* Epidermal hyperplasia
*Appearance of epithelioid cells with occasional spindle cells
| [[File:Melanoma.JPG |thumb|none|300px| Vulvar melanoma]]
|-
|}


==References==
==References==

Revision as of 16:56, 9 December 2015

Ovarian cancer Microchapters

Home

Patient Information

Overview

Historical Perspective

Classifications

Pathophysiology

Causes of Ovarian cancer

Differentiating Ovarian cancer from other Diseases

Epidemiology & Demographics

Risk Factors

Screening

Natural History, Complications & Prognosis

Diagnosis

History & Symptoms

Physical Examination

Staging

Laboratory Findings

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Ovarian cancer pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Ovarian cancer pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Ovarian cancer pathophysiology

CDC on Ovarian cancer pathophysiology

Ovarian cancer pathophysiology in the news

Blogs on Ovarian cancer pathophysiology

Directions to Hospitals Treating Ovarian cancer

Risk calculators and risk factors for Ovarian cancer pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Ovarian cancer is often diagnosed late resulting in a poor overall outcome for the patient. Pathological findings, therefore, often only occur in advanced symptomatic onset and tend to present more as severe pathologic outcomes.

Pathophysiology

  • Photomicrograph is from the solid / papillary right ovarian tumor. As shown in this photo, much of the tumor had a papillary pattern with exuberant epithelial proliferation but no obvious stromal invasion. Other areas, such as the one depicted in the second photo, show extensive stromal invasion, the criterion upon which rests the diagnosis of frank malignancy.
    Photomicrograph is from the solid / papillary right ovarian tumor. As shown in this photo, much of the tumor had a papillary pattern with exuberant epithelial proliferation but no obvious stromal invasion. Other areas, such as the one depicted in the second photo, show extensive stromal invasion, the criterion upon which rests the diagnosis of frank malignancy.
  • Extensive stromal invasion, the criterion upon which rests the diagnosis of frank malignancy
    Extensive stromal invasion, the criterion upon which rests the diagnosis of frank malignancy
  • In this TAH-BSO specimen, the right ovary (on the left of the image) has been replaced by a solid serous carcinoma. The contralateral ovarian tumor is grossly cystic and could be termed a "cystadenocarcinoma." The patient had omental metastases and positive peritoneal fluid cytology. This cancer, which was discovered at exploratory laparotomy, apparently developed very rapidly; the patient had a normal pelvic ultrasound exam only 2 months before. (Courtesy of Ed Uthman, MD)
    In this TAH-BSO specimen, the right ovary (on the left of the image) has been replaced by a solid serous carcinoma. The contralateral ovarian tumor is grossly cystic and could be termed a "cystadenocarcinoma." The patient had omental metastases and positive peritoneal fluid cytology. This cancer, which was discovered at exploratory laparotomy, apparently developed very rapidly; the patient had a normal pelvic ultrasound exam only 2 months before. (Courtesy of Ed Uthman, MD)
  • Ovary: Mucinous cystadenocarcinoma: Gross, an excellent image of uterus is in picture and thus illustrates the very large size of the ovarian tumor. Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology
    Ovary: Mucinous cystadenocarcinoma: Gross, an excellent image of uterus is in picture and thus illustrates the very large size of the ovarian tumor.
    Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology


Gross Patholgy

Vulvar Carcinomas Subtype Features on Gross Pathology
Squamous cell carcinoma of vulva
Basal cell carcinoma of vulva
  • Pearly nodule with telangiectasias
Vulvar melanoma
  • Superficial spreading is the most common type
  • Brown/black color, but may include reddish brown or white
  • Hyperkeratotic, diffused borders with no distinct demarcation
  • Irregular and elevated

Microscopic Pathology

Histologic subtypes of vulvar cancer include:[1][2][3][4]

  • Vulvar carcinomas
Vulvar Carcinomas Subtype Features on Histopathological Microscopic Analysis Image
Squamous cell carcinoma of vulva
  • Eosinophilia
  • Extra large nuclei/bizarre nuclei
  • Inflammation (lymphocytes, plasma cells)
  • Long rete ridges
  • Numerous beeds/blobs of epithelial cells that seem unlikely to be rete ridges
Squamous cell carcinoma of vulva
Basal cell carcinoma of vulva
  • Basaloid cells - similar in appearance to basal cells
  • Moderate blue/grey cytoplasm.
  • Dark ovoid/ellipsoid nucleus with uniform chromatin
  • Palisading of cells at the edge of the cell nests
  • Artefactual separation of cells (forming the nests) from the underlying stroma - key feature
  • Surrounded by blue (myxoid) stroma - key feature
Basal cell carcinoma of vulva
Vulvar melanoma
  • Presence of intraepidermal lateral spread (most characteristic feature)
  • Dermal invasion
  • Desmoplasia
  • Epidermal hyperplasia
  • Appearance of epithelioid cells with occasional spindle cells
Vulvar melanoma

References

  1. ↑ Hoffman, Barbara (2012). Williams gynecology. New York: McGraw-Hill Medical. ISBN 9780071716727.
  2. ↑ Malignant melanoma. Libre pathology. http://librepathology.org/wiki/index.php/Malignant_melanoma. URL Accessed on September 30, 2015
  3. ↑ Basal cell carcinoma . Libre pathology. http://librepathology.org/wiki/index.php/Basal_cell_carcinoma. URL Accessed on September 30, 2015
  4. ↑ Squamous cell carcinoma. Libre pathology. http://librepathology.org/wiki/index.php/Squamous_cell_carcinoma. URL Accessed on September 30, 2015


Template:WikiDoc Sources

Retrieved from "https://www.wikidoc.org/index.php?title=Ovarian_cancer_pathophysiology&oldid=1193488"