Primary central nervous system lymphoma MRI: Difference between revisions
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==Overview== | ==Overview== | ||
==MRI== | ==MRI== | ||
[[MRI]] usually shows multiple (1 to 3) 3- to 5-cm ring-enhancing lesions in almost any location, but usually deep in the white matter. The major [[differential diagnosis]] is cerebral [[toxoplasmosis]], which is also prevalent in AIDS patients and also presents with a ring-enhanced lesion, although the contrast enhancement is more pronounced in toxoplasmosis and it presents with more lesions. | [[MRI]] usually shows multiple (1 to 3) 3- to 5-cm ring-enhancing lesions in almost any location, but usually deep in the white matter. The major [[differential diagnosis]] is cerebral [[toxoplasmosis]], which is also prevalent in AIDS patients and also presents with a ring-enhanced lesion, although the contrast enhancement is more pronounced in toxoplasmosis and it presents with more lesions. | ||
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! style="background: #4479BA; width: 150px;" | {{fontcolor|#FFF|MRI component}} | |||
! style="background: #4479BA; width: 370px;" | {{fontcolor|#FFF|Findings}} | |||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |T1 | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Typically hypointense to white matter | |||
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| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|T2 | |||
| style="padding: 5px 5px; background: #F5F5F5;" |Variable | |||
*Majority are iso- to hypointense | |||
**Isointense: 33% | |||
**Hypointense: 20% | |||
*Hyperintense: 15-47%, more common in tumors with [[necrosis]] | |||
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| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|T1 with gadolinium contrast | |||
| style="padding: 5px 5px; background: #F5F5F5;" |*Typical high grade tumors demonstrate intense homogeneous enhancement while low-grade tumors have absent to moderate enhancement | |||
*Peripheral ring enhancement may be observed in [[immunocompromised patients]] (HIV/AIDS) | |||
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| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|Diffusion-weighted imaging (DWI)/Apparent diffusion coefficient (ADC) | |||
| style="padding: 5px 5px; background: #F5F5F5;" |*Typical restricted diffusion | |||
*More restricted diffusion and lower ADC values compared to [[glioma|high-grade gliomas]] and [[intarcerebral metatstases|metastases]] | |||
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==References== | ==References== | ||
Revision as of 14:27, 18 February 2016
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Primary central nervous system lymphoma Microchapters |
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Differentiating Primary Central Nervous System Lymphoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Primary central nervous system lymphoma MRI On the Web |
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American Roentgen Ray Society Images of Primary central nervous system lymphoma MRI |
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Directions to Hospitals Treating Primary central nervous system lymphoma |
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Risk calculators and risk factors for Primary central nervous system lymphoma MRI |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
MRI
MRI usually shows multiple (1 to 3) 3- to 5-cm ring-enhancing lesions in almost any location, but usually deep in the white matter. The major differential diagnosis is cerebral toxoplasmosis, which is also prevalent in AIDS patients and also presents with a ring-enhanced lesion, although the contrast enhancement is more pronounced in toxoplasmosis and it presents with more lesions.
| MRI component | Findings |
|---|---|
| T1 | Typically hypointense to white matter |
| T2 | Variable
|
| T1 with gadolinium contrast | *Typical high grade tumors demonstrate intense homogeneous enhancement while low-grade tumors have absent to moderate enhancement
|
| Diffusion-weighted imaging (DWI)/Apparent diffusion coefficient (ADC) | *Typical restricted diffusion
|