Primary central nervous system lymphoma other diagnostic studies: Difference between revisions
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Because imaging techniques cannot distinguish the two conditions with certainty, patients usually undergo [[brain biopsy]] if the lesion is solitary or a trial of toxoplasmosis therapy is non-therapeutic. In the future, it may be possible to use [[polymerase chain reaction|PCR]] assay of cerebrospinal fluid for EBV DNA. | Because imaging techniques cannot distinguish the two conditions with certainty, patients usually undergo [[brain biopsy]] if the lesion is solitary or a trial of toxoplasmosis therapy is non-therapeutic. In the future, it may be possible to use [[polymerase chain reaction|PCR]] assay of cerebrospinal fluid for EBV DNA. | ||
==References== | ===Magnetic Resonance Spectroscopy=== | ||
[[In vivo magnetic resonance spectroscopy|Magnetic resonance spectroscopy]] may be diagnostic of primary central nervous system lymphoma. Findings on [[In vivo magnetic resonance spectroscopy|MR spectroscopy]] suggestive of primary central nervous system lymphoma include:<ref name=radiographicfeaturesofprimarycnslymphoma1>Radiographic features of primary CNS lymphoma. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/primary-cns-lymphoma. Accessed on February 18, 2016</ref> | |||
*Large [[choline]] peak | |||
*Reversed [[choline]]/[[creatinine]] ratio | |||
*Markedly decreased [[N-Acetylaspartate|N-Acetylaspartate (NAA)]] | |||
*[[Lactate]] peak may also be observed | |||
==References== | |||
{{Reflist|2}} | {{Reflist|2}} | ||
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[[Category:Viral diseases]] | [[Category:Viral diseases]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Oncology]] | |||
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{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
Revision as of 14:43, 18 February 2016
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Primary central nervous system lymphoma Microchapters |
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Differentiating Primary Central Nervous System Lymphoma from other Diseases |
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Diagnosis |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Primary CNS lymphoma is a primary intracranial tumor usually present in those with severe immunosuppression --- commonly in those with AIDS --- and represents around 20% of all cases of lymphomas in HIV infection (other types being Burkitt's lymphoma and immunoblastic lymphoma).
Other Diagnostics Studies
Because imaging techniques cannot distinguish the two conditions with certainty, patients usually undergo brain biopsy if the lesion is solitary or a trial of toxoplasmosis therapy is non-therapeutic. In the future, it may be possible to use PCR assay of cerebrospinal fluid for EBV DNA.
Magnetic Resonance Spectroscopy
Magnetic resonance spectroscopy may be diagnostic of primary central nervous system lymphoma. Findings on MR spectroscopy suggestive of primary central nervous system lymphoma include:[1]
- Large choline peak
- Reversed choline/creatinine ratio
- Markedly decreased N-Acetylaspartate (NAA)
- Lactate peak may also be observed
References
- ↑ Radiographic features of primary CNS lymphoma. Dr Amir Rezaee and A.Prof Frank Gaillard et al. Radiopaedia 2016. http://radiopaedia.org/articles/primary-cns-lymphoma. Accessed on February 18, 2016