Diffuse large B cell lymphoma laboratory tests: Difference between revisions

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Revision as of 17:16, 28 August 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Laboratory tests of follicular lymphoma include cytology, genetic testing, histologic confirmation, and immunophenotyping.

Laboratory tests of follicular lymphoma include

Histologic confirmation
ImmunophenotypingBCL-2+, BCL6+/-, CD10+, CD15+, CD20+, CD22+, CD30+, CD79a+, EBNA-2+, Fox-P1+, IRF4/MUM1+, LMP-1+, Surface 4 or cytoplasmic immunoglobulin (Ig) is absent

@@ Line 9: / Line 9: @@
 *[[Cytology]] (for primary CNS lymphoma only)
 *[[Genetic testing]]
+:*8q24/''MYC'' [[translocations]]
+:*Immunoglobulin genes clonally rearranged and hypermutated
+:*Mutation of ''BCL6'', ''MYC'', ''PAX5'', ''PIM1'', ''RhoH''/''TTFn'', ''TP53'' genes
+:*Translocations involving ''c-MYC'', ''BCL6'', and ''IgH'' genes
 * Histologic confirmation
-*[[Immunophenotyping]]
+*[[Immunophenotyping]]''BCL-2+'', ''BCL6+/-'', ''[[CD10]]+'', [[CD15]]+, [[CD20]]+, [[CD22]]+, [[CD30]]+, [[CD79a]]+, EBNA-2+, Fox-P1+, [[IRF4]]/MUM1+, LMP-1+, Surface 4 or cytoplasmic [[immunoglobulin]] (Ig) is absent
 ==References==