Diffuse large B cell lymphoma laboratory tests: Difference between revisions

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==Overview==
==Overview==
Laboratory tests of diffuse large B cell lymphoma include [[cytology]], [[genetic testing]], histologic confirmation, and [[immunophenotyping]].
Laboratory tests of diffuse large B cell lymphoma include [[complete blood count]], blood chemistry studies, [[flow cytometry]], [[immunohistochemistry]], [[cytology]], [[genetic testing]], and [[immunophenotyping]].
==Laboratory Tests==
==Laboratory Tests==
Laboratory tests of diffuse large B cell lymphoma include<ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref><ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>:
Laboratory tests of diffuse large B cell lymphoma include<ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref><ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref>:
*[[Cytology]] (for primary CNS lymphoma only)
* [[Complete blood count]] (CBC)
*[[Genetic testing]]
* Blood chemistry studies
* [[Flow cytometry]]
* [[Immunohistochemistry]]
* [[Cytology]] (for primary CNS lymphoma only)
* [[Genetic testing]]
:*8q24/''MYC'' [[translocations]]  
:*8q24/''MYC'' [[translocations]]  
:*Immunoglobulin genes clonally rearranged and hypermutated  
:*Immunoglobulin genes clonally rearranged and hypermutated  
:*Mutation of ''BCL6'', ''MYC'', ''[[PAX5]]'', ''[[PIM1]]'', ''[[RhoH]]''/''TTFn'', ''[[TP53]]'' genes  
:*Mutation of ''BCL6'', ''MYC'', ''[[PAX5]]'', ''[[PIM1]]'', ''[[RhoH]]''/''TTFn'', ''[[TP53]]'' genes  
:*Translocations involving ''c-MYC'', ''BCL6'', and ''[[IgH]]'' genes
:*Translocations involving ''c-MYC'', ''BCL6'', and ''[[IgH]]'' genes
* Histologic confirmation
* [[Immunophenotyping]] ''BCL-2+'', ''BCL6+/-'', [[CD10]]+, [[CD15]]+, [[CD20]]+, [[CD22]]+, [[CD30]]+, [[CD79a]]+, EBNA-2+, Fox-P1+, [[IRF4]]/MUM1+, LMP-1+, Surface 4 or cytoplasmic [[immunoglobulin]] (Ig) is absent
*[[Immunophenotyping]] ''BCL-2+'', ''BCL6+/-'', ''[[CD10]]+'', [[CD15]]+, [[CD20]]+, [[CD22]]+, [[CD30]]+, [[CD79a]]+, EBNA-2+, Fox-P1+, [[IRF4]]/MUM1+, LMP-1+, Surface 4 or cytoplasmic [[immunoglobulin]] (Ig) is absent


==References==
==References==

Revision as of 19:43, 1 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Laboratory tests of diffuse large B cell lymphoma include complete blood count, blood chemistry studies, flow cytometry, immunohistochemistry, cytology, genetic testing, and immunophenotyping.

Laboratory Tests

Laboratory tests of diffuse large B cell lymphoma include[1][1]:

  • 8q24/MYC translocations
  • Immunoglobulin genes clonally rearranged and hypermutated
  • Mutation of BCL6, MYC, PAX5, PIM1, RhoH/TTFn, TP53 genes
  • Translocations involving c-MYC, BCL6, and IgH genes

References

  1. ↑ 1.0 1.1 National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov


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