Waldenström's macroglobulinemia natural history, complications and prognosis: Difference between revisions
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{{Waldenström's macroglobulinemia}} | {{Waldenström's macroglobulinemia}} | ||
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==Overview== | ==Overview== | ||
==Natural History, Complications and Prognosis== | ==Natural History, Complications and Prognosis== | ||
===Natural History=== | |||
*Most patients with Waldenström's macroglobulinemia are initially asymptomatic. If left untreated, most of the patients will develop symptomatic Waldenström's macroglobulinemia. | |||
===Complication=== | |||
*Common complications of Waldenström's macroglobulinemia include: | |||
:*Late complications: | |||
::*Richter's transformation also Known as Large Cell Transformation<ref name="iwmf">Waldenström's macroglobulinemia. International Waldenström's macroglobulinemia Foundation (2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September 25, 2015</ref> | |||
::*Bing-Neel Syndrome - Central Nervous System Lymphoma | |||
Current medical treatments result in survival some longer than 10 years. In part this is because better diagnostic testing means early diagnosis and treatments. Older diagnosis and treatments resulted in published reports of median survival of approximately 5 years from time of diagnosis.<ref name="Cheson"> </ref> New treatments have made longer term survival a reality for many with this condition. In rare instances, WM progresses to [[multiple myeloma]].<ref name="Johansson">{{cite journal | author=Johansson B, Waldenstrom J, Hasselblom S, Mitelman F | title=Waldenstrom's macroglobulinemia with the AML/MDS-associated t(1;3)(p36;q21) | journal=Leukemia | year=1995 | pages=1136-8 | volume=9 | issue=7 | id=PMID 7630185}}</ref> | Current medical treatments result in survival some longer than 10 years. In part this is because better diagnostic testing means early diagnosis and treatments. Older diagnosis and treatments resulted in published reports of median survival of approximately 5 years from time of diagnosis.<ref name="Cheson"> </ref> New treatments have made longer term survival a reality for many with this condition. In rare instances, WM progresses to [[multiple myeloma]].<ref name="Johansson">{{cite journal | author=Johansson B, Waldenstrom J, Hasselblom S, Mitelman F | title=Waldenstrom's macroglobulinemia with the AML/MDS-associated t(1;3)(p36;q21) | journal=Leukemia | year=1995 | pages=1136-8 | volume=9 | issue=7 | id=PMID 7630185}}</ref> | ||
Revision as of 19:12, 10 November 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mirdula Sharma, MBBS [2]
Overview
Natural History, Complications and Prognosis
Natural History
- Most patients with Waldenström's macroglobulinemia are initially asymptomatic. If left untreated, most of the patients will develop symptomatic Waldenström's macroglobulinemia.
Complication
- Common complications of Waldenström's macroglobulinemia include:
- Late complications:
- Richter's transformation also Known as Large Cell Transformation[1]
- Bing-Neel Syndrome - Central Nervous System Lymphoma
Current medical treatments result in survival some longer than 10 years. In part this is because better diagnostic testing means early diagnosis and treatments. Older diagnosis and treatments resulted in published reports of median survival of approximately 5 years from time of diagnosis.[2] New treatments have made longer term survival a reality for many with this condition. In rare instances, WM progresses to multiple myeloma.[3]
References
- ↑ Waldenström's macroglobulinemia. International Waldenström's macroglobulinemia Foundation (2015) https://en.wikipedia.org/wiki/Medulloblastoma Accessed on September 25, 2015
- ↑ Invalid
<ref>tag; no text was provided for refs namedCheson - ↑ Johansson B, Waldenstrom J, Hasselblom S, Mitelman F (1995). "Waldenstrom's macroglobulinemia with the AML/MDS-associated t(1;3)(p36;q21)". Leukemia. 9 (7): 1136–8. PMID 7630185.