Wilms' tumor causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Overview

Wilms' tumor may be caused by either genetic mutations or chromosomal alterations.

Causes

• Genetic mutations:

• Wilms tumor 1 gene (WT1)
• WT2
• WTX

• Other genes and chromosomal alterations:

• 1q
• 16q and 1p
• CACNA1E
• 7p21
• SKCG-1
• TP53 (tumor suppressor gene)
• FBXW7
• PTCH1
• DICER1
• MYCN