Ganglioglioma pathophysiology

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Pathophysiology

Gross Pathology

There is predilection towards the temporal lobes.

Microscopic Pathology

Gangliogliomas are composed of two cell populations:

• Ganglion cells (large mature neuronal elements): ganglio-
• Neoplastic glial elements (primarily astrocytic): -glioma

It is the grade of the glial component that determines biological behaviour. Dedifferentiation into high grade tumours does occasionally occur, and it is usually the glial component (into a glioblastoma multiforme). Only rarely is it the neuronal component (into a neuroblastoma).

Markers

Neuronal origin is demonstrated by positivity to neuronal markers:

• Synaptophysin
• Neuronal specific enolase
• GFAP marker

References

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