Ganglioglioma pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
===Gross Pathology=== | ===Gross Pathology=== | ||
There is predilection towards the [[temporal lobes]], although gangliglioma may occur in the [[frontal lobe]], [[parietal lobe]], [[occipital lobe]], and regions of the [[thalamus]] and [[third ventricle]] | There is predilection towards the [[temporal lobes]]<ref name=dd>Pathophysiology of ganglioglioma. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioglioma</ref>, although gangliglioma may also occur in the [[frontal lobe]], [[parietal lobe]], [[occipital lobe]], and regions of the [[thalamus]] and [[third ventricle]] | ||
===Microscopic Pathology=== | ===Microscopic Pathology=== | ||
Revision as of 15:00, 3 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Pathophysiology
Gross Pathology
There is predilection towards the temporal lobes[1], although gangliglioma may also occur in the frontal lobe, parietal lobe, occipital lobe, and regions of the thalamus and third ventricle
Microscopic Pathology
Gangliogliomas are composed of two cell populations:[1]
- Ganglion cells (large mature neuronal elements): ganglio-
- Neoplastic glial elements (primarily astrocytic): -glioma
It is the grade of the glial component that determines biological behaviour. Dedifferentiation into high grade tumours does occasionally occur, and it is usually the glial component (into a glioblastoma multiforme). Only rarely is it the neuronal component (into a neuroblastoma).
Markers
Neuronal origin is demonstrated by positivity to neuronal markers:[1]
- Synaptophysin
- Neuronal specific enolase
- GFAP
References
- ↑ 1.0 1.1 1.2 Pathophysiology of ganglioglioma. Dr Henry Knipe and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/ganglioglioma