Ganglioglioma pathophysiology

Ganglioglioma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Epidemiology and Demographics
Risk Factors
Screening
Differentiating Ganglioglioma from other Diseases
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical Examination
Laboratory Findings
X Ray
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Ganglioglioma pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Ganglioglioma pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA onGanglioglioma pathophysiology
CDC on Ganglioglioma pathophysiology
Ganglioglioma pathophysiology in the news
on Ganglioglioma pathophysiology
Directions to Hospitals Treating Ganglioglioma
Risk calculators and risk factors for Ganglioglioma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Ganglioglioma arises from neuronal glial cells, which are cells of the central nervous system. On gross pathology, ganglioglioma varies from partially cystic mass with a mural nodule to a solid mass expanding the overlying gyrus. On microscopic pathology, it is composed of ganglion cells and neoplastic glial cells. Markers involved in the pathogenesis of ganglioglioma include synaptophysin, neuronal specific enolase, GFAP.

Pathophysiology

Gross Pathology

• There is predilection towards the temporal lobes.
• Other parts where ganglioglioma can occur include:
  • Frontal lobe
  • Parietal lobe
  • Occipital lobe
  • Thalamus
  • Third ventricle
  • Spinal cord
• Their appearance is variable: from a partially cystic mass with an mural nodule (~45% of cases) to a solid mass expanding the overlying gyrus.

Microscopic Pathology

Gangliogliomas are composed of two cell populations:

• Ganglion cells (large mature neuronal elements): ganglio-
• Neoplastic glial elements (astrocytic): -glioma

It is the grade of the glial component that determines biological behaviour. Dedifferentiation into high grade tumours does occasionally occur, and it is usually the glial component (into a glioblastoma multiforme). Only rarely it is the neuronal component (into a neuroblastoma).

Markers

Neuronal origin is demonstrated by positivity to neuronal markers:

• Synaptophysin
• Neuronal specific enolase
• GFAP

References

Template:WikiDoc Sources