Hodgkin's lymphoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Hodgkin's lymphoma may be classified according to World Health Organization (WHO) into 2 subtypes: nodular lymphocyte predominance and classical Hodgkin's lymphoma.

Classification

Hodgkin's lymphoma may be classified according to World Health Organization (WHO) into 2 subtypes:

• Nodular lymphocyte predominance

• Classical Hodgkin's lymphoma

• Nodular sclerosing
• Mixed cellularity
• Lymphocyte rich
• Lymphocyte depleted

Classical Hodgkins lymphoma classification

Name	Description
Nodular sclerosing	Most common subtype and is composed of large tumor nodules showing scattered lacunar classical Reed–Sternberg cells set in a background of reactive lymphocytes, eosinophils, and plasma cells with varying degrees of collagen fibrosis/sclerosis.
Mixed-cellularity	Common subtype and is composed of numerous classic Reed-Sternberg cells admixed with numerous inflammatory cells including lymphocytes, histiocytes, eosinophils, and plasma cells without sclerosis. This type is most often associated with Epstein–Barr virus (EBV) infection and may be confused with the early, so-called 'cellular' phase of nodular sclerosing classical Hodgkins lymphoma.
Lymphocyte rich	Rare subtype, show many features which may cause diagnostic confusion with nodular lymphocyte predominant B-cell Non-Hodgkin's Lymphoma (B-NHL). This form also has the most favorable prognosis.
Lymphocyte depleted	Rare subtype, composed of large numbers of often pleomorphic Reed-Sternberg cells with only few reactive lymphocytes which may easily be confused with diffuse large cell lymphoma. Many cases previously classified within this category would now be reclassified under anaplastic large cell lymphoma.

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