Ganglioneuroma pathophysiology

Ganglioneuroma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Pathophysiology

Gross Pathology

• Ganglioneuromas are solid, firm tumors that are typically white when seen with the naked eye
• Gangliocytoma is commonly located in the following regions:
  • Abdomen (most common)
  • Adrenal gland
  • Paraspinal retroperitoneum
  • Posterior mediastinum
  • Neck

Microscopic Pathology

• Ganglioneuromas are derived from the primordial neural crest cells, which are undifferentiated cells of the sympathetic nervous system.
• Ganglioneuromas are fully differentiated neuronal tumors that do not contain immature elements.
• They are composed of ganglion cells, schwann cells and fibrous tissue.

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