Adrenolipoma pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
On gross pathology, central congested, red to brown lesion with thin cortical rim is a characteristic finding of adrenolipoma. On microscopic histopathological analysis, variable amounts of [[adipocytes]] and [[hematopietic cells]] are characteristic findings of adrenolipoma. | On gross pathology, central congested, red to brown lesion with thin cortical rim is a characteristic finding of adrenolipoma. On microscopic histopathological analysis, variable amounts of [[adipocytes]] and [[hematopietic cells]] are characteristic findings of adrenolipoma. | ||
==Pathogenesis== | |||
The most widely accepted theory in pathogenesis of adrenolipoma is the existence of [[metaplasia]] of the [[reticuloendothelial cells]] of blood [[capillaries]] in the [[adrenal gland]] in response to stimuli such as [[necrosis]], [[infection]], or [[stress]]. | The most widely accepted theory in pathogenesis of adrenolipoma is the existence of [[metaplasia]] of the [[reticuloendothelial cells]] of blood [[capillaries]] in the [[adrenal gland]] in response to stimuli such as [[necrosis]], [[infection]], or [[stress]]. | ||
==Gross Pathology== | ==Gross Pathology== | ||
Revision as of 13:39, 9 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
On gross pathology, central congested, red to brown lesion with thin cortical rim is a characteristic finding of adrenolipoma. On microscopic histopathological analysis, variable amounts of adipocytes and hematopietic cells are characteristic findings of adrenolipoma.
Pathogenesis
The most widely accepted theory in pathogenesis of adrenolipoma is the existence of metaplasia of the reticuloendothelial cells of blood capillaries in the adrenal gland in response to stimuli such as necrosis, infection, or stress.
Gross Pathology
Macroscopic examination demonstrates:[1]
Central congested, red to brown lesion with thin cortical rim, large lesions may contain haemorrhage or infarction
Microscopic Pathology
Histological examination demonstrates:[1]
- Variable amounts of mature adipocytes (with distended lipid vacuoles) similar to bone marrow
- Variable amounts of hematopoietic cells (including cells from myeloid, erythroid and megakaryocytic cells lines)