Hepatocellular carcinoma pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
On microscopic histopathological analysis, large polygonal tumours cells with graunular eosinophilic cytoplasm or layered dense collagen bundles are characteristic findings of hepatocellular carcinoma | On microscopic histopathological analysis, large polygonal tumours cells with graunular eosinophilic cytoplasm or layered dense collagen bundles are characteristic findings of hepatocellular carcinoma. | ||
==Gross Pathology== | ==Gross Pathology== | ||
Revision as of 14:12, 10 September 2015
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Hepatocellular carcinoma Microchapters |
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Differentiating Hepatocellular carcinoma from other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Hepatocellular carcinoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Hepatocellular carcinoma pathophysiology |
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Risk calculators and risk factors for Hepatocellular carcinoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Parminder Dhingra, M.D. [2] Mohamad Alkateb, MBBCh [3]
Overview
On microscopic histopathological analysis, large polygonal tumours cells with graunular eosinophilic cytoplasm or layered dense collagen bundles are characteristic findings of hepatocellular carcinoma.
Gross Pathology
- Nodular or diffusely infiltrative
- The nodular type may be unifocal (large mass) or multifocal (when developed as a complication of cirrhosis). Tumor nodules are round to oval, grey or green (if the tumor produces bile), well circumscribed but not encapsulated
- Tumours are multifocal in approx. 50% of cases; some authors have suggested it is upto 75% of cases
- The diffuse type is poorly circumscribed and infiltrates the portal veins, or the hepatic veins (rarely)
- Pale in relation to surrounding liver or green (due to bile secretion)
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Hepatocelluler carcinoma. The image shows a longitudinal slice taken through the full length of the liver.
(Courtesy of Ed Uthman, MD) -
The tumor is at the top, cirrhotic liver at the bottom, and a fibrous reaction in between. Hepatocellular carcinomas can have a variety of gross patterns, including multinodular / multifocal, such as this one.
(Courtesy of Ed Uthman, MD)
Microscopic Pathology
- Large polygonal tumours cells with:
- Graunular eosinophilic cytoplasm
- Low NC ratio
- Layered dense collagen bundles [1]
Videos
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