Hodgkin's lymphoma laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Laboratory tests for Hodgkin's lymphoma include complete blood count (CBC), blood chemistry studies, HIV blood test, immunohistochemistry, erythrocyte sedimentation rate, and immunophenotyping.

Laboratory Tests

Laboratory tests for Hodgkin's lymphoma include the following:

• Complete blood count (CBC)is done to:

• Rule out infection
• Assess how well the blood-forming organs (such as the bone marrow and spleen) are working and to see if Hodgkin's lymphoma cells have spread to the bone marrow
• Provide a baseline for future blood counts taken during and after treatment

• Blood chemistry studies include:

• Protein levels
• Liver function tests
• Kidney function tests
• Uric acid level

• HIV blood test
• Immunohistochemistry helps determine the types of cells that are present, including Hodgkin and Reed-Sternberg cells
• Erythrocyte sedimentation rate
• Immunophenotyping:

• Nodular lymphocyte predominant: CD19+, CD20+, CD22+, CD15-, CD30-
• Classical Hodgkin's lymphoma: CD15+, CD30+, CD20-, CD45-

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