Pheochromocytoma natural history, complications and prognosis: Difference between revisions
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*[[Refractory hypertension]] | *[[Refractory hypertension]] | ||
*[[Malignant hypertension]] | *[[Malignant hypertension]] | ||
*[[Metastasis]] to [[lymph nodes]], [[bones]], [[lungs]], and [[liver]] | *[[Metastasis]] to [[lymph nodes]], [[bones]], [[lungs]], and [[liver]] | ||
===Prognosis=== | ===Prognosis=== | ||
The 5-year survival in the setting of metastatic disease (whether identified at the time of initial diagnosis or identified postoperatively as recurrent disease) is 40% to 45%. | The 5-year survival in the setting of metastatic disease (whether identified at the time of initial diagnosis or identified postoperatively as recurrent disease) is 40% to 45%. | ||
Revision as of 18:14, 11 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ahmad Al Maradni, M.D. [2]
Overview
Prognosis of pheochromocytoma is generally good but metastatic pheochromocytoma has a 5 year survival rate of approximately 45%.[1] Massive release of catecholamines can causes damage to myocytes.
Natural History, Complication and Prognosis
Complication
The massive release of catecholamines in pheochromocytoma can cause damage to myocytes.[2] This damage may be due to either compromising the coronary microcirculation or by direct toxic effects on the myocytes.[2] Other complication may include:
- Hyperglycemia
- Refractory hypertension
- Malignant hypertension
- Metastasis to lymph nodes, bones, lungs, and liver
Prognosis
The 5-year survival in the setting of metastatic disease (whether identified at the time of initial diagnosis or identified postoperatively as recurrent disease) is 40% to 45%.
References
- ↑ National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/pheochromocytoma/hp/pheochromocytoma-treatment-pdq#link/_25_toc
- ↑ 2.0 2.1 Goldman 2011, pp. 327