Multiple myeloma differential diagnosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Multiple myeloma must be differentiated from monoclonal gammopathy of undetermined significance(MGUS), isolated plasmacytoma of the bone, and extramedullary plasmacytoma.

Multiple Myeloma Differential Diagnosis

Diseases with similar symptoms

• Bone fracture - this includes lytic bone tumors such as:

• Fibrous dysplasia
• Enchondroma
• Eosinophilic granuloma
• Giant cell tumor
• Osteoblastoma
• Aneurysmal bone cyst
• Solitary bone cyst
• Hyperparathyroidism
• Infection
• Chondroblastoma
• Chondromyxoid Fibroma

• Reactive plasmacytosis
• Macroglobulinemia
• Bone metastatic tumor
• Other plasma cell disorders such as:

• Monoclonal Gammopathies of Uncertain Origin
• Waldenstrom Hypergammaglobulinemia

References

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