Non-Hodgkin lymphoma classification: Difference between revisions

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{{CMG}}; {{AE}} {{AS}}
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==Overview==
==Overview==
 
Non-Hodgkin lymphoma may be classified into 2 Groups: low-grade lymphoma and high-grade lymphoma
==Classification of Non-Hodgkin lymphoma==
==Classification of Non-Hodgkin lymphoma==
 
Non-Hodgkin lymphoma may be classified into 2 Groups:<ref name=CCS>{{cite web | title = Canadian Cancer Society Grades of non-Hodgkin lymphoma
 
| url =http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/grading/?region=ab}}</ref>
* Low-grade or Indolent lymphoma
* High-grade or Aggressive lymphoma


{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
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| style="padding: 5px 5px; background: #F5F5F5;" | Low-grade or Indolent lymphoma
| style="padding: 5px 5px; background: #F5F5F5;" | Low-grade or Indolent lymphoma
| style="padding: 5px 5px; background: #F5F5F5;" | Indolent lymphomas tend to grow very slowly and there often are few symptoms in the beginning. Because of this, indolent lymphomas tend to widespread by the time they are diagnosed, often involving the bone marrow and spleen.
| style="padding: 5px 5px; background: #F5F5F5;" | Tend to grow very slowly and there often are few symptoms in the beginning. Because of this, indolent lymphomas tend to widespread by the time they are diagnosed, often involving the bone marrow and spleen.<BR>Often treated only when symptoms appear.<BR>Can shrink or sometimes seem to disappear with treatment, but they tend to come back.<BR>Have a fairly good prognosis.<BR>Some indolent lymphomas can change (transform) into more aggressive lymphomas and so need more aggressive treatment.
 
Indolent lymphomas may need little or no treatment for months or even years. They are often treated only when symptoms appear.
 
Indolent lymphomas can shrink or sometimes seem to disappear with treatment, but they tend to come back.
 
Indolent lymphomas have a fairly good prognosis. People can live many years, although indolent lymphomas are difficult to cure.
 
Some indolent lymphomas can change (transform) into more aggressive lymphomas and so need more aggressive treatment.
 
Read more: http://www.cancer.ca/en/cancer-information/cancer-type/non-hodgkin-lymphoma/grading/?region=ab#ixzz3m1ioIsUu
|-
|-
| style="padding: 5px 5px; background: #F5F5F5;" |  
| style="padding: 5px 5px; background: #F5F5F5;" | High-grade or Aggressive lymphoma
| style="padding: 5px 5px; background: #F5F5F5;" | Common subtype and is composed of numerous classic Reed-Sternberg cells admixed with numerous inflammatory cells including lymphocytes, [[histiocytes]], eosinophils, and plasma cells without sclerosis. This type is most often associated with  [[Epstein–Barr virus]] (EBV) infection and may be confused with the early, so-called 'cellular' phase of nodular sclerosing classical Hodgkins lymphoma.
| style="padding: 5px 5px; background: #F5F5F5;" | Grow quickly and tend to spread to lymph nodes or other organs throughout the body.<BR>They usually cause symptoms and need treatment right away.<BR>Aggressive lymphomas tend to respond well to treatment.<BR>Aggressive lymphomas can frequently be successfully treated with intensive chemotherapy treatment.
|}
|}
Over the years, doctors have used a variety of terms to classify the many different types of non-Hodgkin's lymphoma . Most often, they are grouped by how the cancer cells look under a [[microscope]] and how quickly they are likely to grow and spread.  Current lymphoma classification is complex. 
[[MeSH]] includes four different criteria for classifying NHL. (It is possible to be classified under more than one.)
* High-grade vs. intermediate vs. low-grade: Aggressive lymphomas, also known as intermediate and high-grade lymphomas, tend to grow and spread quickly and cause severe symptoms. Indolent lymphomas, also referred to as low-grade lymphomas, tend to grow quite slowly and cause fewer symptoms.  One of the paradoxes of non-Hodgkin's lymphoma is that the indolent lymphomas generally cannot be cured by [[chemotherapy]], while in a significant number of cases aggressive lymphomas can be.
* Diffuse vs. follicular: [[Follicular lymphoma]] tends to be indolent, and [[diffuse lymphoma]] tends to be aggressive.
* [[T-cell lymphoma]] vs. [[B-cell lymphoma]]
** [[Gluten-sensitive_enteropathy_associated_conditions#GSEA_Lymphoma|Gluten-sensitive enteropathy associated T-cell lymphoma]] or EATL
* Large cell lymphoma (such as [[anaplastic large cell lymphoma]]) vs. [[Small cell lymphoma]] vs. Mixed cell lymphoma
Details of the most popular classifications of lymphoma can be found in the [[lymphoma]] page.


==References==
==References==
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{{Hematology}}
{{Hematology}}
{{Hematological malignancy histology}}
{{Hematological malignancy histology}}
[[bn:অ-হজকিনের লসিকার্বুদ]]
[[de:Non-Hodgkin-Lymphom]]
[[es:Linfomas no-Hodgkins]]
[[fr:Lymphome non-hodgkinien]]
[[nl:Non-Hodgkin]]
[[ja:非ホジキンリンパ腫]]
[[pl:Chłoniaki nieziarnicze]]
[[pt:Linfoma não-Hodgkin]]
[[fi:Non-Hodgkinin lymfooma]]
[[sv: Non-Hodgkins lymfom]]


[[Category:Hematology]]
[[Category:Hematology]]

Revision as of 20:01, 17 September 2015

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Non-Hodgkin lymphoma may be classified into 2 Groups: low-grade lymphoma and high-grade lymphoma

Classification of Non-Hodgkin lymphoma

Non-Hodgkin lymphoma may be classified into 2 Groups:[1]

  • Low-grade or Indolent lymphoma
  • High-grade or Aggressive lymphoma
Classical Non-Hodgkin lymphoma classification
Grade Description
Low-grade or Indolent lymphoma Tend to grow very slowly and there often are few symptoms in the beginning. Because of this, indolent lymphomas tend to widespread by the time they are diagnosed, often involving the bone marrow and spleen.
Often treated only when symptoms appear.
Can shrink or sometimes seem to disappear with treatment, but they tend to come back.
Have a fairly good prognosis.
Some indolent lymphomas can change (transform) into more aggressive lymphomas and so need more aggressive treatment.
High-grade or Aggressive lymphoma Grow quickly and tend to spread to lymph nodes or other organs throughout the body.
They usually cause symptoms and need treatment right away.
Aggressive lymphomas tend to respond well to treatment.
Aggressive lymphomas can frequently be successfully treated with intensive chemotherapy treatment.

References

  1. ↑ "Canadian Cancer Society Grades of non-Hodgkin lymphoma".

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